Learner1
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Folks, the reality is something like this (courtesy of Sigma Aldrich):
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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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That's not what the data says....There is no evidence that ME is due to nutritional deficiency.
"We confirm reports of altered plasma levels of choline, carnitine and complex lipid metabolites and demonstrate that patients with ME/CFS and IBS have increased plasma levels of ceramide."
Recent studies by Naviaux et al. (2016) demonstrated abnormalities in energy metabolism that affected mitochondrial function in patients with ME/CFS. Oxidative stress markers have been reported as abnormal in ME/CFS with finding showing reduced antioxidants levels and increased markers of oxidative damage (Maes et al. 2011; Kennedy et al. 2005).
Figuring out what the disturbance is, though I don´t thing that it´s an infection.If you have a bacterial infection then tell your doctor and get on some antibiotics.
I again agree. All the tendencies which have been more or less consistently found will hardly account for the disease. Its much more likely that they are downstream-effects.Ceramides are apoptosis signalers and oxidation is revved up in apoptosis too. You are looking at aborted apoptosis.
Thank you. And very interesting observation - thank you again!... I am bedridden 4 years now and playing with transdermal delivery because i cannot tolerate oraldelivery and have been abandoned by healthcare system.....there seems to be an order and a 'listening within' of when to up doses etc. Although i show deficiencies of many vitamins on bloodwork, i do not think bloodwork is yet sensitive enough to see how its getting in some of our cells etc. I appreciate this thread.
This was one that I found particularly interesting..Eighty percent of the diagnostic metabolites were decreased, consistent with a hypometabolic syndrome. Pathway abnormalities included sphingolipid, phospholipid, purine, cholesterol, microbiome, pyrroline-5-carboxylate, riboflavin, branch chain amino acid, peroxisomal, and mitochondrial metabolism."
https://www.pnas.org/content/113/37/e5472
...................... ...............................I................................................................................ II...........................................................
.................................................with food................................................ probably three or four out of the five in a period
A: inhibitory: .... monoamine transporter enhancer ............................. 1. VitB12
.............................. esp. for Dopamine: Luteolin (carefully) .................... 2. MgCl
.............................. or (maybe less good) ...................................................... 3. VitC
.............................. Dopamine receptor blocker (carefully) ......................4. Acetate
............................................................................................................................... 5. K
...............................normal dose added in food.................................. esp. here with tendency to single dose(!)
B: excitatory: ... Dopamine precursor Tyrosine ....................................... some of the amono acids
............................................................................................................................... (only?) some of the metals
.................................................................................................................................some of the B´s: B2 -B1 - B7 - (B3);
..................................................................................................................................................................B5 (!), B6 (?)
................................................................................................................................. other
.............................................................................................................................normal dose
.............................................................................................................................Mg, Se
Again small amounts in water.
......................A.........................................B....................................C
3. .....BCAA's (+Cr)......................B3 + TRP.......................B7 (+Cr)
2. ..............B5 (+ Ni)................................................................B1 (+Ni)
1. ..............LYS + Fe.................................................................B2 (+Zi)
B3 - TRP - ratio in capsulae..............................................in weight
09 : 1......................................................................................................144 : 250
10 : 1......................................................................................................166 : 250
11 : 1 best so far! but TRP soleley is no good.........................182 : 250
VitC
Acetate
MgCl
B12
K
occasionally taken.retarding zinc supp (125 mg does already the job)
B3+TRP ..................................VitC
B7 ...........BCAA .....Cr ..........K?
B1 ...........B5 ............Ni ..........B12
B2 .......... LYS ..........FE ..........Cl
.................................- Zn - ..................
This application actually works now relatively very good. I guess it must realy be small amounts: just as much, that good action would be served, but not that much, that also bad actions from the past would be served.first three columns I can tak at least now alltogether, very easy then, but even smaler amounts.
(thereby B2 lowest, and so on, needs to be checked out after having gotten a feeling)
then sometimes inhibitory stuff.
3. ..........................Cr ......... B7 .......... B3 / TRP
2. ..........................Ni ......... B1
1. ... BCAA ....... Fe ......... B2
3. ..........................Cr ......... ?? ........... B3 / TRP
2. ..........................Ni ......... B5
1. ... BCAA ....... Fe ......... LYS
To my surprice tyrosin fits in here. Indeed strong.So, one strong influence woud be missing, probably an amino acid.
Now, there are two parts of the pallidus:........................... caudatus ........... accumbens / caudatus
.......................... putamen
caudatus ..... pallidus