My hypothesis certainly isn't based on PhD level understanding, nor on the kind of studies that labs do. My personal observations are consistent with the core problem being neurological. The physical symptoms common to the majority of PWME could, I think, quite easily be caused by a single hard-to-find neurological dysfunction. One little change in a reaction rate can have cascading effects throughout the body.
I do feel that the existence of a subgroup without the common physical symptoms is reasonably strong evidence for those symptoms to be secondary, rather than primary. Those physical symptoms being secondary (or tertiary or whatever) seems much more likely than the subgroup having a defence or counter to physical symptoms while retaining the neurological ones.
I do feel that the existence of a subgroup without the common physical symptoms is reasonably strong evidence for those symptoms to be secondary, rather than primary. Those physical symptoms being secondary (or tertiary or whatever) seems much more likely than the subgroup having a defence or counter to physical symptoms while retaining the neurological ones.