Pramipexole put my CFS/ME into remission

[DonPepe]

Mine was the same - a slow decline, likely caused by my unwillingness to stop pushing myself.

On the Bell scale, started around 60 maybe 25 years ago (triggered by virus or vaccine - I'm not sure which). By ten years ago it was down to 30 which was miserable enough. Then a bad extended allergic reaction dropped me down to 15, and been there for over five years. The constant headache / head pressure, cognitive crashes, etc - that's the worst.

I know exactly how you feel.

 

[Webby04]

I definitely think mine is dopamine related. I haven't tried LDA - considering it, but concerned about long term effects of some of those types of medications.

How did you end up getting pramipexole? And what kind of risks did you consider?

I got it from my rheumatologist. I’ve heard of DAWS. Which scares me a little bit

 

[Webby04]

Never mind everyone. It seems to be wearing off/stopping to work. Been the worst 12 hours.. so looks like it only lasted 6 weeks or so

 

[junkcrap50]

That’s a great idea. I just assumed tolerance would build up regardless..
I’m not sure what you mean by your question sorry mate?

How long did it take for the abilify wear off? how slow or fast?

 

[Webby04]

How long did it take for the abilify wear off? how slow or fast?

Only took 6 weeks then it stopped working

 

[bad1080]

But clearly for me this is a dopamine issue

they way i get a big boost after a LSD trip (which also acts on the dopamine receptor) makes me think that too or at least the boost in dopamine is able to suppress/overcome the underlying issue

 

[DonPepe]

they way i get a big boost after a LSD trip (which also acts on the dopamine receptor) makes me think that too or at least the boost in dopamine is able to suppress/overcome the underlying issue

Hmm there is anecdotal evidence here and on Reddit that people get relief microdosing mushrooms. Is there a link?

 

[bad1080]

Hmm there is anecdotal evidence here and on Reddit that people get relief microdosing mushrooms. Is there a link?

psilocybin does not interact with dopamine receptors only serotonin. i do get relief from microdosing it but more in the depression and suicidal ideation department, it helps much less with my energy/fatigue. i did try md'ing lsd for a bit but i found the energy it gives me to be "borrowed" (from tomorrow).

 

[hmnr asg]

Hmm there is anecdotal evidence here and on Reddit that people get relief microdosing mushrooms. Is there a link?

i have microdosed shrooms, zero relief and i have not read of anyone saying they got relief from microdosing shrooms (as nice as it is, wont help cfs).

 

[junkcrap50]

Only took 6 weeks then it stopped working

I would guess that's allows a down time of ~2-3 weeks enough time to allow for any downregulation to reset.