godlovesatrier
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Chronic Fatigue Syndrome: Naltrexone as an Alternative Treatment
At low doses, naltrexone is thought to disrupt the inflammatory process and restore the impaired cation channel functioning associated with chronic fatigue. Inside the latest data.
Authors: Danielle Weitzer, DO
Date: 18th June 2020
I haven't been able to find this article on PR so thought I would post it here.
https://www.practicalpainmanagement...gue-syndrome-naltrexone-alternative-treatment
At low doses, naltrexone is thought to disrupt the inflammatory process and restore the impaired cation channel functioning associated with chronic fatigue. Inside the latest data.
Authors: Danielle Weitzer, DO
Date: 18th June 2020
Anti-inflammatory and Hyperalgesia Effects
At a much lower dosage of 3.0 mg to 4.5 mg per day, it is the non-opioid antagonist path that is more active, which is believed to exert the anti-inflammatory and hyperalgesia effects.2 In this path, naltrexone simultaneously has an antagonist effect on non-opioid receptors, including toll-like receptor 4 (TLR 4), that are found on macrophages such as microglia.2 Microglia are central nervous system immune cells that are activated by a wide range of triggers.3
Restoring TRPM3 Ion Channel Function
In addition to this perspective, and more recently, there has been an association found between abnormal cation channel functioning and chronic fatigue. Transient receptor potential melastatin 3 (TRPM3) is a calcium permeable nonselective channel that is activated by a vast array of stimuli in the environment, ranging from temperature, natural chemicals, and toxins or synthetic compounds. As it tightly controls the influx of calcium ions, this channel is essential in maintaining natural killer cell functioning and cytokine production. A significant reduction in both TRPM3 surface expression and intracellular calcium mobilization in natural killer cells has been found in chronic fatigue patients compared with healthy controls.7
I haven't been able to find this article on PR so thought I would post it here.
https://www.practicalpainmanagement...gue-syndrome-naltrexone-alternative-treatment