Postinfectious and CF Syndromes: Clinical Experience from Norway

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Tom Kindlon posted this to CO-CURE today

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[B]Postinfectious and Chronic Fatigue Syndromes: Clinical Experience from a Tertiary-referral Centre in Norway[/B]


H Naess, E Sundal, KM Myhr, and HI Nyland

In Vivo, March 1, 2010; 24(2): 185-8.

Department of Neurology, Haukeland University Hospital, University of
Bergen, N-5021 Bergen, Norway. halvor.naess@haukeland.no.

BACKGROUND: We aimed to compare patients reporting acute infection with
those reporting no infection at onset of chronic fatigue syndrome (CFS).

PATIENTS AND METHODS: This study includes 873 patients with CFS referred to
a tertiary centre on average 4.8 years after symptom onset. Assessment was
by both observer query and self-reports. Antibody analyses against
infectious agents including Epstein-Barr virus and enterovirus were
performed in a majority of patients.

RESULTS: Females comprised 75.3% of the patient group, and the mean age was
33 years. Initial infection was reported by 77%. There was no difference as
to antibody analyses. Logistic regression showed that initial infection was
independently associated with acute onset of fatigue, improvement of fatigue
at referral, and the following symptoms at referral: fever, tender lymph
nodes, and myalgia.

CONCLUSION: CFS patients with initial infection as a precipitating factor
more often report acute onset of fatigue, more frequent accompanying
symptoms, and more frequent improvement on referral than do patients without
initial infection.

PMID: 20363992

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