SmokinJoeFraz93
Senior Member
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Polygala is used in Chinese medicine, and I was recommended it for it’s effective NMDA antagonist properties. Polygala has multiple qualities that I think could potentially help certain individuals with ME/CFS.
The recommended daily dose is 100mg, x3 daily. The effects start to appear within 20 minutes. A sense of calmness within my brain and a very noticeable decrease in central fatigue and pain sensitivity.
I began to take Polygala mainly for my severe sensory overload, that saw me housebound in isolation and silence for 13 months due to me not being able to tolerate sensory/stimuli. I can honestly say, Polygala reduces my sensory issues by a good 70-80%, and I rely on marijuana to fill the remaining percentage.
I haven’t noticed any side effects whatsoever, and it’s gentle on the stomach. I’ve recently taken Memantine, and I find Memantine a tiny little bit stronger. However, the effectiveness in sensory overload reduction is just the same for myself. I have also tried Kava root, and I personally felt the effects of Polygala much more so than Kava.
Polygala’s Potential Therapeutic Qualities
. NMDA Antagonist
. Triple Reuptake Inhibitor - Serotonin, Norepinephrine & Dopamine
. BDNF Increase/Regulation
. Anti inflammatory effects in Microglial Cells
. Memory Improvement
The link below will provide a more in-depth list of therapeutic qualities of Polygala
https://examine.com/supplements/polygala-tenuifolia/
I believe the extract of Polygala used in the studies in the link I’ve provided (above), is the product I bought from Nootropic Depot. I opted for the powdered version as a serving size (100mg) is relatively small in powder quantity. You can however, choose the capsules. The links are provided below.
Polygala Extract (Powder) - https://nootropicsdepot.com/polygala-tenuifolia-20-1-extract-powder-yuan-zhi/
Polygala Extract (Capsules) - https://nootropicsdepot.com/polygala-tenuifolia-20-1-extract-100mg-capsules-yuan-zhi/
I use this company to buy my CoQ10 powder, and have never had an issue. The quality and shipping (USA to the UK) has been ‘on point’.
*EDIT* - As for antidepressant qualities, it is in my opinion that Polygala is much more effective and potent than St John’s Wort and 5htp combined.
The recommended daily dose is 100mg, x3 daily. The effects start to appear within 20 minutes. A sense of calmness within my brain and a very noticeable decrease in central fatigue and pain sensitivity.
I began to take Polygala mainly for my severe sensory overload, that saw me housebound in isolation and silence for 13 months due to me not being able to tolerate sensory/stimuli. I can honestly say, Polygala reduces my sensory issues by a good 70-80%, and I rely on marijuana to fill the remaining percentage.
I haven’t noticed any side effects whatsoever, and it’s gentle on the stomach. I’ve recently taken Memantine, and I find Memantine a tiny little bit stronger. However, the effectiveness in sensory overload reduction is just the same for myself. I have also tried Kava root, and I personally felt the effects of Polygala much more so than Kava.
Polygala’s Potential Therapeutic Qualities
. NMDA Antagonist
. Triple Reuptake Inhibitor - Serotonin, Norepinephrine & Dopamine
. BDNF Increase/Regulation
. Anti inflammatory effects in Microglial Cells
. Memory Improvement
The link below will provide a more in-depth list of therapeutic qualities of Polygala
https://examine.com/supplements/polygala-tenuifolia/
I believe the extract of Polygala used in the studies in the link I’ve provided (above), is the product I bought from Nootropic Depot. I opted for the powdered version as a serving size (100mg) is relatively small in powder quantity. You can however, choose the capsules. The links are provided below.
Polygala Extract (Powder) - https://nootropicsdepot.com/polygala-tenuifolia-20-1-extract-powder-yuan-zhi/
Polygala Extract (Capsules) - https://nootropicsdepot.com/polygala-tenuifolia-20-1-extract-100mg-capsules-yuan-zhi/
I use this company to buy my CoQ10 powder, and have never had an issue. The quality and shipping (USA to the UK) has been ‘on point’.
*EDIT* - As for antidepressant qualities, it is in my opinion that Polygala is much more effective and potent than St John’s Wort and 5htp combined.
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