My mother and her brother got ME-like symptoms when they were in their 40s. My uncle got a disability pension at age 50, although without any specific diagnosis.
My mother could work, she was self employed, and had a room with a bed in her office. At 75 she was diagnosed with Mantle cell lymphoma, and given Rituximab. It seems to have extended her life with a couple of years, but three years later the Rituximab effect is waining.
There are currently no signs of the lymphoma, but her health status reminds very much of my own.
I got my symptoms earlier than they did, and my health in my 50s is worse than their in their 70s. But there are many similarities. (...and some differences, maybe explained by the sex difference.)