Violeta
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https://www.nature.com/articles/s41598-025-93313-w.pdf
Meng Sun1,5, Xinwen Zhang2,5, Xinli Feng3,4 & Lu Liang3
March 28, 2025
Researchon CFS has gradually shifted from symptom management to investigating its molecular mechanisms, withthe role of PKM2 (pyruvate kinase M2) increasingly becoming a focus.
The metabolic patterns in CFS patients have significantlychanged. Studies have found increased glycolytic activity and reduced efficiency of mitochondrial oxidativephosphorylation in CFS patients, leading to energy deficiency and the accumulation of metabolic waste, suchas lactate3.PKM2 plays a crucial role in this process.
Research suggests that abnormal activation of PKM2 in hippocampal cells may enhance glycolysis and lactateaccumulation, leading to mitochondrial dysfunction and accelerating the progression of CFS6. Furthermore, theactivation of PKM2 not only promotes glycolysis but also regulates lactate accumulation, which further alters theacidic environment within cells. This metabolic disorder is considered a crucial mechanism underlying energyproduction deficits in CFS patients.
Meng Sun1,5, Xinwen Zhang2,5, Xinli Feng3,4 & Lu Liang3
March 28, 2025
Researchon CFS has gradually shifted from symptom management to investigating its molecular mechanisms, withthe role of PKM2 (pyruvate kinase M2) increasingly becoming a focus.
The metabolic patterns in CFS patients have significantlychanged. Studies have found increased glycolytic activity and reduced efficiency of mitochondrial oxidativephosphorylation in CFS patients, leading to energy deficiency and the accumulation of metabolic waste, suchas lactate3.PKM2 plays a crucial role in this process.
Research suggests that abnormal activation of PKM2 in hippocampal cells may enhance glycolysis and lactateaccumulation, leading to mitochondrial dysfunction and accelerating the progression of CFS6. Furthermore, theactivation of PKM2 not only promotes glycolysis but also regulates lactate accumulation, which further alters theacidic environment within cells. This metabolic disorder is considered a crucial mechanism underlying energyproduction deficits in CFS patients.