Why haven't drug companies been working on pain relievers based on this information?
"The objectives of this first mini-review written on peroxynitrite and morphine antinociceptive tolerance are to discuss the importance of nitroxidative stress in this process and argue that peroxynitrite is a rational target for therapeutic intervention in pain management. These concepts provide a pharmacological basis for developing inhibitors of peroxynitrite biosynthesis as novel non-narcotic analgesics, thus addressing a large and currently unmet medical need with major socioeconomic consequences."
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2714174/
"The objectives of this first mini-review written on peroxynitrite and morphine antinociceptive tolerance are to discuss the importance of nitroxidative stress in this process and argue that peroxynitrite is a rational target for therapeutic intervention in pain management. These concepts provide a pharmacological basis for developing inhibitors of peroxynitrite biosynthesis as novel non-narcotic analgesics, thus addressing a large and currently unmet medical need with major socioeconomic consequences."
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2714174/