Tate Mitchell posted this to co-cure today
[if: Another Metzger study. Love that they found PEM in all CFS subjects, but am not sure how they measured it. I can't access the full text. I'm a bit confused as they said "neither exercise bout altered elastase activity, IL-1β or complement C4a split product levels", but also said, "Postexercise complement C4a level was identified as a clinically important biomarker for postexertional malaise in people with ME/CFS."
I'm also not clear what the difference is between the 2 types of exercise and when they measured for PEM. Look forward to the full text.
Love the use of the word "biomarker"
Love that they're calling for more research into measuring PEM. ]
Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1β
Journal of Internal Medicine, Volume 267, Number 4, April 2010 , pp. 418-435(18)
Nijs, J.; Van Oosterwijck, J.; Meeus, M.; Lambrecht, L.1; Metzger,
K.2; Frmont, M.2; Paul, L.3
(Vrije Universiteit Brussel, Brussels; University College
Antwerp, Antwerp; University Hospital Brussels, Brussels; Private
Practice for Internal Medicine, Gent/Aalst; and RED Laboratories N.V.,
Zellik; Belgium, and University of Glasgow, Glasgow, UK).
http://www.ingentaconnect.com/content/bsc/jint/2010/00000267/00000004/art00009
Abstract:
Objectives. Too vigorous exercise or activity increase frequently
triggers postexertional malaise in people with myalgic
encephalomyelitis/chronic fatigue syndrome (ME/CFS), a primary
characteristic evident in up to 95% of people with ME/CFS. The present
study aimed at examining whether two different types of exercise
results in changes in health status, circulating elastase activity,
interleukin (IL)-1β and complement C4a levels.
Design. Comparative experimental design.
Setting. University.
Subjects. Twenty-two women with ME/CFS and 22 healthy sedentary
controls Interventions: participants were subjected to a submaximal
exercise (day 8) and a self-paced, physiologically limited exercise
(day 16). Each bout of exercise was preceded and followed by blood
sampling, actigraphy and assessment of their health status.
Results. Both submaximal exercise and self-paced, physiologically
limited exercise resulted in postexertional malaise in people with
ME/CFS.
However, neither exercise bout altered elastase activity,
IL-1β or complement C4a split product levels in people with ME/CFS or
healthy sedentary control subjects (P > 0.05).
Postexercise complement C4a level was identified as a clinically important biomarker for
postexertional malaise in people with ME/CFS.
Conclusions. Submaximal exercise as well as self-paced,
physiologically limited exercise triggers postexertional malaise in
people with ME/CFS, but neither types of exercise alter acute
circulating levels of IL-1β, complement C4a split product or elastase
activity. Further studying of immune alterations in relation to
postexertional malaise in people with ME/CFS using multiple
measurement points postexercise is required.
Keywords: chronic fatigue syndrome; exercise; fibromyalgia; immunity;
pain; postexertional malaise
Document Type: Research article
DOI: 10.1111/j.1365-2796.2009.02178.x
Affiliations: 1: Private Practice for Internal Medicine, Gent/Aalst 2:
RED Laboratories N.V., Zellik, Belgium 3: Nursing and Health Care,
Faculty of Medicine, University of Glasgow, Glasgow, UK
[if: Another Metzger study. Love that they found PEM in all CFS subjects, but am not sure how they measured it. I can't access the full text. I'm a bit confused as they said "neither exercise bout altered elastase activity, IL-1β or complement C4a split product levels", but also said, "Postexercise complement C4a level was identified as a clinically important biomarker for postexertional malaise in people with ME/CFS."
I'm also not clear what the difference is between the 2 types of exercise and when they measured for PEM. Look forward to the full text.
Love the use of the word "biomarker"
Love that they're calling for more research into measuring PEM. ]
Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1β
Journal of Internal Medicine, Volume 267, Number 4, April 2010 , pp. 418-435(18)
Nijs, J.; Van Oosterwijck, J.; Meeus, M.; Lambrecht, L.1; Metzger,
K.2; Frmont, M.2; Paul, L.3
(Vrije Universiteit Brussel, Brussels; University College
Antwerp, Antwerp; University Hospital Brussels, Brussels; Private
Practice for Internal Medicine, Gent/Aalst; and RED Laboratories N.V.,
Zellik; Belgium, and University of Glasgow, Glasgow, UK).
http://www.ingentaconnect.com/content/bsc/jint/2010/00000267/00000004/art00009
Abstract:
Objectives. Too vigorous exercise or activity increase frequently
triggers postexertional malaise in people with myalgic
encephalomyelitis/chronic fatigue syndrome (ME/CFS), a primary
characteristic evident in up to 95% of people with ME/CFS. The present
study aimed at examining whether two different types of exercise
results in changes in health status, circulating elastase activity,
interleukin (IL)-1β and complement C4a levels.
Design. Comparative experimental design.
Setting. University.
Subjects. Twenty-two women with ME/CFS and 22 healthy sedentary
controls Interventions: participants were subjected to a submaximal
exercise (day 8) and a self-paced, physiologically limited exercise
(day 16). Each bout of exercise was preceded and followed by blood
sampling, actigraphy and assessment of their health status.
Results. Both submaximal exercise and self-paced, physiologically
limited exercise resulted in postexertional malaise in people with
ME/CFS.
However, neither exercise bout altered elastase activity,
IL-1β or complement C4a split product levels in people with ME/CFS or
healthy sedentary control subjects (P > 0.05).
Postexercise complement C4a level was identified as a clinically important biomarker for
postexertional malaise in people with ME/CFS.
Conclusions. Submaximal exercise as well as self-paced,
physiologically limited exercise triggers postexertional malaise in
people with ME/CFS, but neither types of exercise alter acute
circulating levels of IL-1β, complement C4a split product or elastase
activity. Further studying of immune alterations in relation to
postexertional malaise in people with ME/CFS using multiple
measurement points postexercise is required.
Keywords: chronic fatigue syndrome; exercise; fibromyalgia; immunity;
pain; postexertional malaise
Document Type: Research article
DOI: 10.1111/j.1365-2796.2009.02178.x
Affiliations: 1: Private Practice for Internal Medicine, Gent/Aalst 2:
RED Laboratories N.V., Zellik, Belgium 3: Nursing and Health Care,
Faculty of Medicine, University of Glasgow, Glasgow, UK