Peckerman - Hypoperfusion in CFS/POTS leads to PENE

[adreno]

Resveratrol inhibits isoprostanes, and improve cerebral blood flow:

Resveratrol inhibits isoprostane production in young and aged rat brain.

Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation.

 

[ramakentesh]

Dr Bell's views are not established and certainly not accepted by all researchers. Vanderbilt are currently reviewing whether abnormalities in kidney dopamine levels may effect postural salt handling and consequently overall blood volume.
Secondly many of the findings of abnormal autoregulation by Stewart and Medow point to impaired venous pressure and or changes in neuronal blood flow changes.
Finally the ventricular lactate studies are interesting given hits proximity to the hypothalamus.

 

[ramakentesh]

Resveratrol inhibits isoprostanes, and improve cerebral blood flow:

Resveratrol inhibits isoprostane production in young and aged rat brain.

Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation.

Do you tolerate red wine? It also potently effects nitric oxide bioavailability - which may be adverse considering there is strong evidence of nitric oxide upregulation in many POTS patients.

 

[ramakentesh]

And according to one of the researchers involved in a more recent research paper on ventricular lactate, the view that the etiological framework of primary cerebral antioxidant abnormalities is not uniformly accepted even in that group.

Impaired glucose metabolism alone can account for increased cerebral lactate. As can reduced blood flow from any of the pathological mechanisms in POTS and OI, many of which there is strong evidence for peripheral abnormalities rather than central.

Cerebral autoregulation in POTS with CFS was found to be poorly buffered, resulting in no buffering of BP variations in the cerebral vasculature. This again does not support this hypothesis.

 

[ramakentesh]

with a potent vasoconstrictor
effect on peripheral vasculature lead to decreased regional
cerebral blood flow, with consequent increases in anaerobic
glycolysis and brain lactate, the end product of glycolysis

Presuming peripheral vasoconstriction was a common finding in CFS with OI. WHich is isnt. Secondly how does this account for increases of norepinephrine and angiotensin II and potential baroreflex abnormalities?

 

[Emootje]

Personally, I'm a big fan of Bell's hypovolemic vasoconstriction theory. I my case it explains a lot and it looks something like this:



It explains the hypovolemia and the secondary vasoconstriction response (SNS an RAAS). The same mechanism (high isoprostane/ET-1/ANP, hypovolemia, SNS and RAAS activation) are seen in diseases like obstructive jaundice/cholestase, pre-eclampsia and liver cirrhosis.

ANP = Atrial Natriuretic Peptide
ET-1 = Endotheline-1
SNS = sympathetic nervous system
RAAS = Renin–Angiotensin–Aldosterone System

 

[xchocoholic]

Hi All,

I'm bumping this because I was telling someone here about this article by Peckerman. HTH ... X

 

[xrayspex]

Hi All,

I'm bumping this because I was telling someone here about this article by Peckerman. HTH ... X

hey xchocoholic I was researching and came upon this thread again and wanted to follow up---you had mentioned that you were able to deal with a lot of your symptoms through diet etc Would you mind saying how that is going for you now and what you have found to be the most useful in dealing with these issues? what drinking, eating, supplementing, resting etc habits? (I was going to PM you but looks like you aren't open for that option?)