PEA / Palmitoylethanolamide causing anxiety


Senior Member
Hi all, I took a dose of PEA on Sunday evening and have been having a lot of anxiety and a little pain and agitation since.

Does anyone know what the mechanism could be?
.I'm wondering if this can cause die off? Or know what might help?

YippeeKi YOW !!

Senior Member
Second star to the right ...
.I'm wondering if this can cause die off?
"Die off", or the Herxheimer's reaction. is largely a myth, generally used to explain the negative effects of the more natural or alternative treatments rather than admit they were a poor choice and the body is reacting to something it doesnt much like....

Other than that useless bit of info, I got nada ....

PEA belongs to the endocannabinoid family, a group of fatty acid amides that have been studied for their pain relieving effects ... PEA triggers the release of two neurotransmitters: dopamine and norepinephrine, so you might be reacting to that.