PDK inhibitors

[mariovitali]

@adreno : Regarding GAS6

Because warfarin inhibited the hypertrophic effect of Gas6/Axl and activa- tion of the Akt/mTOR pathway in vivo, we examined whether Gas6 can activate the Akt/mTOR pathway in mesangial cells in vitro. After stimulation of mesangial cells with the indicated concentrations of Gas6 for 30 min, phosphorylation of Akt, p70 S6 kinase, and 4E-BP-1 was examined by Western blotting. As shown in Fig. 15.7, Gas6 increased phosphorylation of Akt, p70 S6 kinase, and 4E-BP-1 in mesangial cells. The same dose of Gla-defective Gas6 did not affect their phosphorylation. Thus, Gas6 can activate the Akt/mTOR pathway in vitro.

Reference :

https://www.elsevier.com/books/vitamin-k/litwack/978-0-12-374113-4

 

[adreno]

@mariovitali

As you know, Gas6 is a vitamin K dependent enzyme. But perhaps this discussion belongs in the mTOR thread.

 

[ukxmrv]

I've just popped a Rantidine (Zantac) actually, not sure if Tagamet is available in the UK...let's see what happens!

Tagamet is available through Ebay in the UK or online chemists

Zantac does nothing for my ME symptoms but I am yet to try Tagamet

 

[AdamS]

Ugh side effects?

Just made me feel a bit spaced out for about 2 hours and brought back some mild stomach issues. Seemed to subside pretty quick though. No real benefit for me, gunna try Tagamet though soon.

 

[knackers323]

Thanks guys, yeah I was putting a lot of hope into Rapamycin I even stopped my other mTor supplements. I just sent my doc at OMI to ask about continuing with Rapamycin. I broke it down into immediate effects from Akt and long term effects from B cells. It's pretty clear to me it's not going to have a miraculous effect at this point, but it may if I continue it long enough. Similarly @AdamS I've tried hundreds of meds and supps and nothing has stopped the progression of this illness. Pretty frustrating.

you still on the rapamycin @eljefe19 ?

 

[eljefe19]

you still on the rapamycin @eljefe19 ?

Yup I have changed my dosing up according to everyone's suggestions here. I'm doing 3mg twice a week. Doin' alright ask me in a couple months though.

 

[knackers323]

@eljefe19 it took a little while to start working did it?

 

[frozenborderline]

https://www.scbt.com/scbt/browse/pdk-Inhibitors/_/N-1594us9

 

[godlovesatrier]

A quote from the Reddit thread with an update on how this person did. Just in case anyone else like me went looking for how this person got on with the drug:

@Tunguska I felt pretty sure I was improving 2-3 days into starting Rapamycin but I'm a week in now at 1mg and the last two days have been pretty standard PEM. Suffice to say I'm not feeling any tremendous relief from Akt activation. I shouldn't have by now shouldn't I? I've now tried several Akt activators without any great results.