FUNCTIONAL GENETICS, INC. (Gaithersburg, MD, US)
"Antibodies to TSG101 can be effective diagnostics to identify individuals with a predisposition to prostate. They can also be used in place of current diagnostics to confirm the presence of prostate cancer. TSG101 antibodies, when administered in vivo, exhibit the ability to reduce tumor size, suppress metastatic transformation and extend survival.
Applicants have now demonstrated that cells, in particular, prostate cells, infected with XMRV, can be detected by antibody binding to TSG101 on the surface of the cells, where uninfected cells show no binding (by staining) by the same antibodies. Antibodies, both polyclonal and monoclonal, to TSG101 are widely available. This presents a new, powerful method to detect XMRV infection. Male patients testing positive for XMRV infection should be considered in a higher risk category for development of aggressive prostate cancer, and appropriate diagnostics, behavior modification and therapy initiated.