PACE Trial and PACE Trial Protocol
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Graham
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No, that was the fourth take, and although he usually settles down and nods off, all the activity around kept him semi-alert. CBT to him probably means Could Be Tasty - he seems to eat just about anything. And make no mistake, take him out into our local Ashdown Forest, and he goes through the mud and shrubs like any other spaniel.
Glad you appove of the video.
By the way, as you, like all people of sound mind,are a fan of Terry Pratchett, have you seen Steven Wetherell's first book (well, a trilogy - in e-book form)? For a first book it is very much on the right tracks.
Glad you appove of the video.
By the way, as you, like all people of sound mind,are a fan of Terry Pratchett, have you seen Steven Wetherell's first book (well, a trilogy - in e-book form)? For a first book it is very much on the right tracks.
Another great video. Though I think your dog looked a little nervous when you said "CBT" ... maybe it's heard about that one before?
Although a dog that behaved like this might be more impressive:
Esther12
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http://forums.phoenixrising.me/inde...d-releasing-data-on-recovery-from-pace.20243/
New thread on the 'remission' data from PACE.
New thread on the 'remission' data from PACE.
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At what point is there enough evidence regarding the flimsiness of the PACE trial to support some serious pressure on the Lancet?
While the Lancet has deflected PACE criticism before, I think as many informed public demands for a retraction (frankly you can all but ignore dealing with the Lancet directly) could possibly provide enough egg on the face to make it very hard to keep this paper and remain a respected journal at the same time.
From a legal point of view, it's probably in either the funders hands, or the Lancet's hands to do anything about it, so perhaps a little public relations is the order of the day.
The other possibility is commissioning an independent report, although, it would probably have to be set up by a trusted advocate who ties all participants to non-disclosure agreements, to stop certain grubby paws getting near it. Followed by releasing the report fairly unexpectedly. I'd miss a few dinners to help pay for that
While the Lancet has deflected PACE criticism before, I think as many informed public demands for a retraction (frankly you can all but ignore dealing with the Lancet directly) could possibly provide enough egg on the face to make it very hard to keep this paper and remain a respected journal at the same time.
From a legal point of view, it's probably in either the funders hands, or the Lancet's hands to do anything about it, so perhaps a little public relations is the order of the day.
The other possibility is commissioning an independent report, although, it would probably have to be set up by a trusted advocate who ties all participants to non-disclosure agreements, to stop certain grubby paws getting near it. Followed by releasing the report fairly unexpectedly. I'd miss a few dinners to help pay for that
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I understand that there are good people still working to get the Lancet to address problems with the PACE trial. Unfortunately, Richard Horton, the editor, has already taken a position in defence of the research and researchers so it is going to be difficult to get it changed. An independent analysis of the data is an excellent idea but would be very costly and so far the data has not been released. It might be just as good if the researchers had published or made available ALL the analysis that was done/collated but not published. There must be a great deal of it.
I was wondering what liabilities the Lancet and queen mary's carry if GET harms patients when they have failed to publish acurate results. With the Lancet it is an interesting question since they have been told about the many problems with the way the trial was reported and have claimed to have looked into them.
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Oh yeah, Richard Horton has completely dug his heels on a PACE. I also think that's what makes work like yours (which btw, you have my deepest thanks for) so important. When you can't get in through the front door, you can still park a lorry full of speakers outside the building and play Joe Pasquele's "I know a song that'll get on your nerves" on infinite repeat.
Bob
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Maybe it would be a good idea to make a political push for an independent analysis of the PACE data.
Graham
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Have any of you seen the writings by Peter Kemp?
www.scribd.com/doc/112491377/An-Alternative-Cost-Analysis-of-the-PACE-Trial
www.scribd.com/peter_kemp_7
www.scribd.com/doc/112491377/An-Alternative-Cost-Analysis-of-the-PACE-Trial
www.scribd.com/peter_kemp_7
Bob
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Keep up Graham!
http://forums.phoenixrising.me/index.php?threads/pace-trial-media-coverage-uk.20245/
(Peter has posted links to his work in the above thread.)
Graham
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Thanks Bob, I'm practising for Strictly. Slow, slow, thick, thick, slow. And now I am going to take a vow of silence in order to develop my wisdom. With a bit of luck it will last a good eight hours (the silence, not the wisdom: that will be very transitory).
Bob
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Action for ME website
The analysis was ostensibly on the basis of treatment intention. This is the correct way to analyse the results of a randomised controlled trial, because if the analysis only involves those subjects who complete the trial, it disregards any participants who drop out because of adverse effects, and may therefore give an unjustifiably favourable impression of the treatment under examination.
The authors state, though: “We excluded participants from the intention-to-treat population for whom we had no primary outcome data in the final analysis.”
In other words, this was not an intention-to-treat analysis at all, since only data regarding participants who stayed the course long enough for outcomes to be assessed were included in it.
http://www.actionforme.org.uk/get-informed/news/archived-news/research-news/2011/pace-trial/getting-pace-into-perspective.htm
The analysis was ostensibly on the basis of treatment intention. This is the correct way to analyse the results of a randomised controlled trial, because if the analysis only involves those subjects who complete the trial, it disregards any participants who drop out because of adverse effects, and may therefore give an unjustifiably favourable impression of the treatment under examination.
The authors state, though: “We excluded participants from the intention-to-treat population for whom we had no primary outcome data in the final analysis.”
In other words, this was not an intention-to-treat analysis at all, since only data regarding participants who stayed the course long enough for outcomes to be assessed were included in it.
http://www.actionforme.org.uk/get-informed/news/archived-news/research-news/2011/pace-trial/getting-pace-into-perspective.htm
Bob
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Action for ME said:
I don't think that I've come across this before. It seems significant. But I think they included the drop out rates, didn't they? And if my memory serves me well, the drop out numbers were not very high, and would not have made much difference to the final analysis, if they'd been included.
Bob
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Yes, I'd noticed that. If 30% dropped out because they were too ill to participate, then it would have inflated the very low scores.
Bob
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Is there a discussion thread on the forum about CBT/GET (for CFS) review (meta-analysis) papers, or CBT/GET papers other than PACE and FINE?