For me there was not a lot of difference. My main symptom of brain-fog was associated with both. Until I increased B12 into the 'Freddd range'. Now I seem to be able to take a lot of mfolate. Niacin works like a charm for over-methylation.
It became clear early in treatment that I was not absorbing mfolate well. Instinctively I was drawn to pouring the powder into my buccal pouch. I don't measure the amount that I take and there is some variation day-to-day. I take as much as I am led to take as often as I am led to take it. Usually 2.5 - 3 mg/day. I don't know what this would equate to in swallowed capsules but have not had any success with up to 9 mg/day via that route.
Most try to work up to 1000 mcg and take it from there.... brad