Osteocalcin, CFS connection? Interesting artice.

[Luke]

"Does the key to anti-ageing lie in our bones?"

https://www.theguardian.com/science/2020/jul/04/does-the-key-to-anti-ageing-lie-in-our-bones?

“Osteocalcin acts in muscle to increase the ability to produce ATP, the fuel that allows us to exercise,” says Karsenty. “In the brain, it regulates the secretion of most neurotransmitters that are needed to have memory. The circulating levels of osteocalcin declines in humans around mid-life, which is roughly the time when these physiological functions, such as memory and the ability to exercise, begin to decline.”

 

[Hip]

The article says this:

“Osteocalcin seems to be able to reverse manifestations of ageing in the brain and in muscle,” he says. “What is remarkable is that if you give osteocalcin to old mice, you restore memory and you restore the ability to exercise to the levels seen in a young mouse. That makes it potentially extremely attractive from a medical point of view.”