To explain morphine-induced persistent sensitization, a positive feedback loop has been proposed; this involves an initial morphine-induced amplified release of IL-1β and a subsequent exacerbated release of DAMPs, which increases the activation of TLR4 and the purinergic receptor P2X7R.
I took morphine many years ago for severe fibromyalgia pain. Very soon after I started a very low dose, my ME/CFS got much, much worse. This could very well explain why.
I took morphine many years ago for severe fibromyalgia pain. Very soon after I started a very low dose, my ME/CFS got much, much worse. This could very well explain why.