Opioids operate as pro-inflammatory cytokines, resulting in neuroinflammation in the CNS

[pattismith]

(PDF) Toll-Like Receptor 4 (TLR4)/Opioid Receptor Pathway Crosstalk and Impact on Opioid Analgesia, Immune Function, and Gastrointestinal Motility (researchgate.net)

review 2020

 

[pattismith]

To explain morphine-induced persistent sensitization, a positive feedback loop has been proposed; this involves an initial morphine-induced amplified release of IL-1β and a subsequent exacerbated release of DAMPs, which increases the activation of TLR4 and the purinergic receptor P2X7R.

 

[ljimbo423]

I took morphine many years ago for severe fibromyalgia pain. Very soon after I started a very low dose, my ME/CFS got much, much worse. This could very well explain why.

 

[pattismith]

I took morphine many years ago for severe fibromyalgia pain. Very soon after I started a very low dose, my ME/CFS got much, much worse. This could very well explain why.

I took two years Tramadol for neuropathic pain and got two years of major depression when I stopped.

Every time I take opioids on a regular basis, I feel very good the first day, and I feel like shit every days after...

 

[ljimbo423]

Every time I take opioids on a regular basis, I feel very good the first day, and I feel like shit every days after...

Looking back on my last BIG relapse that took me from mild to severe, I think morphine played a big part in that. I'll never take it again!

 

[bensmith]

I wonder if kratom should be explored or if it’s the same outcome

 

[helen1]

@bensmith
I’ve explored it: same outcome for me. Some people can use it for a longer time before the consequences happen.

 

[belize44]

This is a disturbing concept.