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NSAIDS for Antibody Reduction


Senior Member
East Coast USA
Has anyone considered using NSAIDs for adrenergix and muscarinic antibody producrion? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693360/

Thanks for posting this very interesting study about NSAIDS inhibiting antibody production, @xks201.

Don't know the answer to your question for those specific antibodies. However, polyclonal hypergammaglobulinemia (increased antibodies)has been observed in ME/CFS for decades. Ian Lipkin once remarked it was the only consistent abnormality he's found in his various ME/CFS studies.

The 2012 International Consensus Primer for Medical Practitioners recommends physicians test for it using the protein electrophoresis screen. For patients on NSAIDS would their test results be accurate one wonders? The same goes for studies where participants including controls are taking NSAIDS.

Appears NIH funded a recent study of the effects of NSAIDS on immune functioning following vaccinations so your question is timely and intriguing.


Senior Member
When I was hit by painful neuropathy in 2002, after two years suffering, I took a daily dose of Piroxicam (half tablet a day) during 2 years, and my pain gradually disappeared.

You cannot tell if I got some benefits from the anti-inflammatory or some immune modulation properties of the drug.

At that time, I was not aware my disease was related to some auto-immune process, but now that I have thyroid auto-immunity, high adrenergic and muscarinic antibodies and suspected Small fiber Neuropathy, it is likely that all my symptoms could be auto-immune from the beginning (30 years ago).

The problem with these drugs are the kidney and stomach toxicities.
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