Non-Restorative Sleep in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Fibromyalgia and Chronic or Long Covid is Associated with Immobility which Causes Stasis or Stagnation of Blood Flow and Hypoperfusion.
Investigations and treatments should be directed at the vascular level considering persistent infections that affect blood vessels and cells as the most frequent cause
Abstract
Non-Restorative Sleep (NRS) is the feeling of not having rested after sleeping. Prolonged
immobilization has been shown to cause stasis or stagnation of blood flow.
In the 1990s, the cases of travelers who presented thrombosis due to prolonged
immobilization during a long-term trip were called economy class syndrome. Similarly,
during the 6 to 8 hours of sleep that a person remains immobilized, there will be a greater
stagnation or slowing of blood flow, which is called blood stasis and is recognized as one
of the factors that increases the risk of thrombus or clot formation.
In Chronic or Prolonged COVID, although the NRS is not included among the most
frequent symptoms, other symptoms associated with decreased blood flow and its
stagnation are frequently mentioned, such as numbness or stiffness, tingling and muscle
pain, which usually occur with greater intensity when waking up after sleeping.
Some studies have identified the presence of hypercoagulability and persistent clots in
about 80% of CFS/ME cases. Blood stasis is added to this state of hypercoagulability due
to immobilization during sleep, which will produce greater hypoperfusion, causing the
intensification of symptoms associated with hypoperfusion, especially at the level of the
most peripheral or distal areas of the body, where blood circulation reaches with greater
difficulty, such as the hands, feet and legs.
According to what has been described, it is concluded that the NRS that occurs in CFS/ME
and Fibromyalgia becomes a symptom more associated with Hypoperfusion, Entothelial
Dysfunction and Hypercoagulability.
Considering what has been described, investigations and treatments should be directed
at the vascular level, since the main triggering cause would be persistent endothelial
dysfunction and inflammation, which is most often caused by the presence of persistent
infections by viruses, bacteria or other microorganisms.
The study: https://www.researchgate.net/public...ES_STASIS_OR_STAGNATION_OF_BLOOD_FLOW_AND_HYP
Investigations and treatments should be directed at the vascular level considering persistent infections that affect blood vessels and cells as the most frequent cause
Abstract
Non-Restorative Sleep (NRS) is the feeling of not having rested after sleeping. Prolonged
immobilization has been shown to cause stasis or stagnation of blood flow.
In the 1990s, the cases of travelers who presented thrombosis due to prolonged
immobilization during a long-term trip were called economy class syndrome. Similarly,
during the 6 to 8 hours of sleep that a person remains immobilized, there will be a greater
stagnation or slowing of blood flow, which is called blood stasis and is recognized as one
of the factors that increases the risk of thrombus or clot formation.
In Chronic or Prolonged COVID, although the NRS is not included among the most
frequent symptoms, other symptoms associated with decreased blood flow and its
stagnation are frequently mentioned, such as numbness or stiffness, tingling and muscle
pain, which usually occur with greater intensity when waking up after sleeping.
Some studies have identified the presence of hypercoagulability and persistent clots in
about 80% of CFS/ME cases. Blood stasis is added to this state of hypercoagulability due
to immobilization during sleep, which will produce greater hypoperfusion, causing the
intensification of symptoms associated with hypoperfusion, especially at the level of the
most peripheral or distal areas of the body, where blood circulation reaches with greater
difficulty, such as the hands, feet and legs.
According to what has been described, it is concluded that the NRS that occurs in CFS/ME
and Fibromyalgia becomes a symptom more associated with Hypoperfusion, Entothelial
Dysfunction and Hypercoagulability.
Considering what has been described, investigations and treatments should be directed
at the vascular level, since the main triggering cause would be persistent endothelial
dysfunction and inflammation, which is most often caused by the presence of persistent
infections by viruses, bacteria or other microorganisms.
The study: https://www.researchgate.net/public...ES_STASIS_OR_STAGNATION_OF_BLOOD_FLOW_AND_HYP
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