No Response to T3 with MTHFR Mutations - Please Explain?

[MAF14]

Will do, thanks again!

 

[picante]

@MAF14, I ran across some interesting info:

Attenuation of thyroid hormone action by 1,25-dihydroxyvitamin D3 in pituitary cells.

I've taken straight T3 for several years: Cynomel, which is now unavailable. Cytomel works just as well. Neither one "fixed" everything, but I had improvement in digestion, myofascial pain, body temp, energy, and my horribly low blood pressure came up.

I have high 1,25 D (calcitriol), which is how I ran across this study. Have you had yours tested?

 

[MAF14]

@MAF14, I ran across some interesting info:

Attenuation of thyroid hormone action by 1,25-dihydroxyvitamin D3 in pituitary cells.

I've taken straight T3 for several years: Cynomel, which is now unavailable. Cytomel works just as well. Neither one "fixed" everything, but I had improvement in digestion, myofascial pain, body temp, energy, and my horribly low blood pressure came up.

I have high 1,25 D (calcitriol), which is how I ran across this study. Have you had yours tested?

Thank you for the link... I have not been tested. Is that something I can get done in a normal lab?

Also have you done anything or made any progress in lowering it?

 

[picante]

Thank you for the link... I have not been tested. Is that something I can get done in a normal lab?

Yes.

Also have you done anything or made any progress in lowering it?

I stopped taking vitamin D, and 1,25 is within range now. 25-Hydroxy D is at the low end (that's the one that always gets tested).