NMR metabolic profiling of serum identifies amino acid disturbances in chronic fatigue syndrome (Armstrong et al., 2012)

[est_sunshine]

Hi all,

Just noticed this newly published study and couldn't find it on the forum. Apologies if another thread has been created that I couldn't see.

http://www.ncbi.nlm.nih.gov/pubmed/22728138

Is this why I feel so good when I eat Chicken soup which is chock full of Glutamine?

 

[Marco]

For those who can't access the full paper (including me) there is some interesting discussion of this study in this blog :

http://questioning-answers.blogspot.fr/2012/06/metabolomics-and-chronic-fatigue.html

I'm not sure I'd regard similar findings in ASD, overtraining syndrome and fibro as unrelated.

 

[Jarod]

I've tried supplementing glutamine directly and can't tolerate it. It puts me in to that excitotoxicity state. Good to know though.

 

[Pyrrhus]

Abstract:

Chronic fatigue syndrome (CFS) is a debilitating multisystem disorder characterised by long-term fatigue with a variety of other symptoms including cognitive dysfunction, unrefreshing sleep, muscle pain, and post-exertional malaise. It is a poorly understood condition that occurs in ~5 in every 1000 individuals.

We present here a preliminary study on the analysis of blood samples from 11 CFS and 10 control subjects through NMR metabolic profiling. Identified metabolites that were found to be significantly altered between the groups were subjected to correlation analysis to potentially elucidate disturbed metabolic pathways.

Our results showed a significant reduction of glutamine (P=0.002) and ornithine (P<0.05) in the blood of the CFS samples. Correlation analysis of glutamine and ornithine with other metabolites in the CFS sera showed relationships with glucogenic amino acids and metabolites that participate in the urea cycle. This indicates a possible disturbance to amino acid and nitrogen metabolism. It would be beneficial to identify any potential biomarkers of CFS for accurate diagnosis of the disorder.

(spacing added for readability)

 

[raghav]

I too cant tolerate glutamine. It increases my heart rate to 100 bpm within minutes.

 

[raghav]

Will supplementing with L-ornithine help ?