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Nitric Oxide Metabolite Production During Exercise in Chronic Fatigue Syndrome: A Case-Control Study
Surez A, Guillamo E, Roig T, Blzquez A, Alegre J, Bermdez J,
Ventura JL, Garca-Quintana AM, Comella A, Segura R, Javierre C.
J Womens Health (Larchmt). 2010 May 14. [Epub ahead of print]
1 Department of Physiological Sciences II, Medical School, University
of Barcelona , L'Hospitalet, Barcelona, Spain .
http://www.ncbi.nlm.nih.gov/pubmed/20469961
Abstract
Abstract Background: Chronic fatigue syndrome (CFS) is a disabling
illness of unknown etiology that is characterized by fatigue
associated with a reduced ability to work, lasting for more than 6
months, and accompanied by a specific set of symptoms. The diagnosis
remains difficult because of the absence of laboratory tests and is,
therefore, made largely on the basis of the symptoms reported by the
patient.
The aim of this study was to analyze differences in blood
nitrate levels in CFS patients and a matched control group after a
physical exercise test.
Methods: Forty-four consecutive female
patients with CFS and 25 healthy women performed an exercise test
using a cycle ergometer with monitoring of cardiopulmonary response.
Blood samples were obtained for biochemical analyses of glucose,
lactate, and nitrates at the beginning (under resting conditions) and
after the maximal and supramaximal tests.
Results: Plasma nitrates
differed between the groups, with higher values in the CFS group (F =
6.93, p = 0.003). Nitrate concentration increased in relation to
workload and reached higher values in the CFS group, the maximum
difference with respect to the control group being 295% (t = 4.88, p <
0.001).
Conclusions: The main result of the present study is that
nitric oxide (NO) metabolites (nitrates) showed a much higher increase
after a maximal physical test in CFS patients than in a group of
matched subjects. This combination (exercise plus NO response
evaluation) may be useful in the assessment of CFS.
PMID: 20469961 [PubMed - as supplied by publisher]
Nitric Oxide Metabolite Production During Exercise in Chronic Fatigue Syndrome: A Case-Control Study
Surez A, Guillamo E, Roig T, Blzquez A, Alegre J, Bermdez J,
Ventura JL, Garca-Quintana AM, Comella A, Segura R, Javierre C.
J Womens Health (Larchmt). 2010 May 14. [Epub ahead of print]
1 Department of Physiological Sciences II, Medical School, University
of Barcelona , L'Hospitalet, Barcelona, Spain .
http://www.ncbi.nlm.nih.gov/pubmed/20469961
Abstract
Abstract Background: Chronic fatigue syndrome (CFS) is a disabling
illness of unknown etiology that is characterized by fatigue
associated with a reduced ability to work, lasting for more than 6
months, and accompanied by a specific set of symptoms. The diagnosis
remains difficult because of the absence of laboratory tests and is,
therefore, made largely on the basis of the symptoms reported by the
patient.
The aim of this study was to analyze differences in blood
nitrate levels in CFS patients and a matched control group after a
physical exercise test.
Methods: Forty-four consecutive female
patients with CFS and 25 healthy women performed an exercise test
using a cycle ergometer with monitoring of cardiopulmonary response.
Blood samples were obtained for biochemical analyses of glucose,
lactate, and nitrates at the beginning (under resting conditions) and
after the maximal and supramaximal tests.
Results: Plasma nitrates
differed between the groups, with higher values in the CFS group (F =
6.93, p = 0.003). Nitrate concentration increased in relation to
workload and reached higher values in the CFS group, the maximum
difference with respect to the control group being 295% (t = 4.88, p <
0.001).
Conclusions: The main result of the present study is that
nitric oxide (NO) metabolites (nitrates) showed a much higher increase
after a maximal physical test in CFS patients than in a group of
matched subjects. This combination (exercise plus NO response
evaluation) may be useful in the assessment of CFS.
PMID: 20469961 [PubMed - as supplied by publisher]