Nicotine seems to be a MAOI of sorts, which would explain why it is used by many people and tends
to be additive, in fact very much so. I have noticed in the past that many people with schizophrenia,
tended to be smokers as well. It would seem that it is used as an anodyne in many people as well.
I very much doubt that nicotine can be rendered non-additive, without resulting in a reduction in MAO inhibition. Perhaps vaping nicotine e-liquid would be of use, but even vaping nicotine is still addictive, although it would be
safer as far as lung capacity or the carcinogenic effects of tobacco use would be, IMO.