taniaaust1
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"NF-{kappa}B Activation Stimulates Transcription and Replication of Xenotropic Murine Leukemia Virus-Related Virus in Human B-lineage and Prostate Carcinoma Cells.
Sakakibara S, Sakakibara K, Tosato G.
Laboratory of Cellular Oncology, and Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA."
Seems the NCI and NIH is doing some good research http://www.ncbi.nlm.nih.gov/pubmed/21270144
Very confuses to a non scientific person such as myself but i still got something out of it and having had mono, found it interesting.
**now im going to look up what NF-kB is.....as im interested what else activates that and what its to do with seeing it promotes XMRV**
Sakakibara S, Sakakibara K, Tosato G.
Laboratory of Cellular Oncology, and Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA."
Seems the NCI and NIH is doing some good research http://www.ncbi.nlm.nih.gov/pubmed/21270144
We identify two NF-κB binding sites (designated κB-1 and κB-2) in the long terminal repeat (LTR) U3 region of XMRV, and demonstrate that both sites bind to the NF-κB component p65/RelA. Mutation of the κB-1 site, but not the κB-2 site, impaired responsiveness to TNFα and LMP1 in reporter assays. A mutant XMRV at the κB-1 site replicated significantly less efficiently than the wild-type XMRV in the prostate carcinoma LNCaP, DU145 and PC3 cell lines, HEK293 cells, the EBV-immortalized cell line IB4 and the Burkitt's lymphoma cell line BJAB. These results demonstrate that TNFα and EBV LMP1 enhance XMRV replication in prostate carcinoma and B-lineage cells through the κB-1 site in the XMRV LTR, suggesting that inflammation, EBV infection and other conditions leading to NF-κB activation may promote XMRV spread in man.
Very confuses to a non scientific person such as myself but i still got something out of it and having had mono, found it interesting.
**now im going to look up what NF-kB is.....as im interested what else activates that and what its to do with seeing it promotes XMRV**