• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

New study from Broderick, Fletcher and Klimas: Biomarkers

Messages
30
New study from Broderick, Fletcher and Klimas:
http://www.ncbi.nlm.nih.gov/pubmed/22732129


From the Facebook page of CFIDS Association of America:

In a review article published June 22, 2012 in Brain, Behavior and Immunity, Drs. Nancy Klimas, Gordon Broderick and Mary Ann Fletcher review biomarkers studied in CFS/ME and other conditions that have fatigue as a major component, including M.S., rheumatoid arthritis and cancer. They propose in the conclusions that "persistent disorders such as CFS/ME and cancer-related fatigue likely correspond to alternative homeostatic states enabled by the body as an adaptive strategy." They suggest that "advances in multiplex laboratory tests and bioinformatics allow fatigue research to advance beyond individual biomarkers to modular patterns of co-expression."

Interesting table:
https://www.facebook.com/photo.php?....74987762107.90825.47921632107&type=1&theater
 

richvank

Senior Member
Messages
2,732
Hi, Camilla.

I haven't gotten a copy of the full paper yet, but judging from the table you posted, I think it will be possible to link all of the biomarkers they have studied to the vicious circle mechanism that is described by the Glutathione Depletion--Methylation Cycle Block hypothesis. This hypothesis is elaborated in the video and slides (slides available by clicking on the blue print below the video) at this site:

http://iaomt.media.fnf.nu/2/skovde_2011_me_kroniskt_trotthetssyndrom/${weburl}

Best regards,

Rich