New Atrial Natriuretic Peptide (ANP) ME/CFS video

August59

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This could definitely play a role in treament and recovery. I hope this gets studied further. I wonder what would be the most effective way in reducing ANP, if that is determined to be a treatment goal. Or, would it be the indirect result of another treatment that may already be available? Thanks
 

valentinelynx

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Yow!

Intriguing ideas, but...

Not realizing my laptop was still connected to our TV audio (from watching video from computer on our TV set-up), I'm trying to peel myself off the ceiling: quite the NE/EPI outflow when the (DRAMATIC!!) music from this little slide show BLASTED out of the 800 W surround sound system! Mind you it's 3 AM...

:eek:

BTW, some references would be nice.

Thanks.
 

Emootje

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Hi August59

I think the best way to lower ANP is by reducing endothelin-1(ET-1) or by blocking the ET-1 receptor.
In table 1 are the factors listed that influence ET-1 secretion.

endothelin-1.JPG
http://www.mayoclinicproceedings.com/content/80/1/84.full.pdf

Removing the origin of the activation of the ET-1 pathway will probably reduce ANP.
In ME/CFS the origin is most likely inflammation. (endotoxin, cytokines, oxidative stress, hypoxia)
Interleukin-8 is not mentioned in table 1 but it is a potent stimulator of ET-1 and according to the research of Mikovits, a very important cytokine in ME/CFS.
With an endothelin receptor inhibitor (bosentan, sitaxentan, ambrisentan, atrasentan) you probably will also reduce ANP. I never tried it because they are to expensive.

Emootje
 

Emootje

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And I thought I made a lot of progress by not using emocore in my ME/CFS video...Im so sorry Valentinelynx.
And Im very sorry for your neighbors.
Here are some references:

ANP - Volume Depletion - Symptoms
Salt-losing nephropathy associated with inappropriate secretion of atrial natriuretic peptide a new clinical syndrome
http://www.springerlink.com/content/rfhe9gb7dbat6ye8/fulltext.pdf
Juan Rodriguez-Soriano and Alfredo Vallo describe a patient with a volume depletion due to high ANP.
Patient symptoms (tiredness, headache, blurred vision, abdominal pain and vomiting)
A remarkable match with ME/CFS symptoms.
Unfortunately they did not look at endothelin-1.

Endothelin - ANP Secretion
Mechanisms of atrial natriuretic peptide secretion from the atrium
http://cardiovascres.oxfordjournals.org/content/68/1/8.full.pdf+html

Sleep Apneu Hypoxia Endothelin ANP - Volume Depletion
Regulation of plasma volume during obstructive sleep apnoea.
http://www.ncbi.nlm.nih.gov/pubmed/10607185

High altitude hypoxia ANP - Volume Depletion Low VO2 max
Operation Everest III: role of plasma volume expansion on V'O2max during prolonged high-altitude exposure
http://jap.physiology.org/content/89/1/29.full.pdf

Endotoxin ANP Volume Depletion
Interaction of platelet-activating factor, spleen and atrial natriuretic peptide in plasma volume regulation during endotoxaemia in rats
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2231185/pdf/tjp0512-0227.pdf
 

WillowJ

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I think it's really cool to make a presentation with your hypothesis. :cool:

I just about jumped out of my chair, too :eek: lol

It would be much stronger if you added the references into the presentation (not just as a list but with the thought process of how they connect), so as to better explain how you came to this conclusion.

Maybe keep the slides you have as the opening, then go on to explain how it would all work to create the outcome of low blood volume (the flow chart was nice but it didn't explain to me how it worked). (You might also cite some references such that PWC's have low blood volume, because we can safely assume the YouTube audience is largely ignorant of the pathology of ME/CFS.)

Consider in-text citations (Rodriguez-Soriano) with an end-list of References.