This could definitely play a role in treament and recovery. I hope this gets studied further. I wonder what would be the most effective way in reducing ANP, if that is determined to be a treatment goal. Or, would it be the indirect result of another treatment that may already be available? Thanks
Not realizing my laptop was still connected to our TV audio (from watching video from computer on our TV set-up), I'm trying to peel myself off the ceiling: quite the NE/EPI outflow when the (DRAMATIC!!) music from this little slide show BLASTED out of the 800 W surround sound system! Mind you it's 3 AM...
Removing the origin of the activation of the ET-1 pathway will probably reduce ANP.
In ME/CFS the origin is most likely inflammation. (endotoxin, cytokines, oxidative stress, hypoxia)
Interleukin-8 is not mentioned in table 1 but it is a potent stimulator of ET-1 and according to the research of Mikovits, a very important cytokine in ME/CFS.
With an endothelin receptor inhibitor (bosentan, sitaxentan, ambrisentan, atrasentan) you probably will also reduce ANP. I never tried it because they are to expensive.
And I thought I made a lot of progress by not using emocore in my ME/CFS video...Im so sorry Valentinelynx.
And Im very sorry for your neighbors.
Here are some references:
ANP - Volume Depletion - Symptoms
Salt-losing nephropathy associated with inappropriate secretion of atrial natriuretic peptide a new clinical syndrome http://www.springerlink.com/content/rfhe9gb7dbat6ye8/fulltext.pdf
Juan Rodriguez-Soriano and Alfredo Vallo describe a patient with a volume depletion due to high ANP.
Patient symptoms (tiredness, headache, blurred vision, abdominal pain and vomiting)
A remarkable match with ME/CFS symptoms.
Unfortunately they did not look at endothelin-1.
I think it's really cool to make a presentation with your hypothesis.
I just about jumped out of my chair, too lol
It would be much stronger if you added the references into the presentation (not just as a list but with the thought process of how they connect), so as to better explain how you came to this conclusion.
Maybe keep the slides you have as the opening, then go on to explain how it would all work to create the outcome of low blood volume (the flow chart was nice but it didn't explain to me how it worked). (You might also cite some references such that PWC's have low blood volume, because we can safely assume the YouTube audience is largely ignorant of the pathology of ME/CFS.)
Consider in-text citations (Rodriguez-Soriano) with an end-list of References.