I honestly don't see why the heterozygotes you have are a major concern.
I understand homozygote mutations are of more concern than hetero, but I don't think that means they can simply be dismissed. They may be completely irrelevant, they may not. I am trying to understand where there may be issues that can be addressed. The odds risks given for many illnesses make it clear that a hetero polymorphism can confer no risk, slightly increased risk or the same increased risk as a homo polymorphism.
Their population frequencies are quite high.
I don't quite know what to think regarding the population frequencies. 23andme test for common polymorphisms and SNPedia has more info on the common polymorphisms rather than the rare ones. The rare ones that I find have very little info and unknown significance. Also, that a polymorphism is common doesn't necessarily mean that it is insignificant. For example a polymorphism present in 40% of the general population is found in more that 95% of people diagnosed with Celiac who have been gene tested. That association is very significant even though it is not the whole picture.
I don't know much about the AHCY gene though. You are hetero in the VDR haplotype but I don't necessarily buy what Yasko et al claim about those VDR SNPs since they believe the wild type baT haplotype is "defective".
I don't know much about any of them really and the confusion and differences in claims make it even more difficult.
I would kill to have CBS heterozygotes. Of all the heterozygotes the A1298c has some significance as it affects BH4 levels directly and the ACAT which affects acetylcoa production, but that one needs additional things beyond simply mb12 and folate. Yes you have a heterozygote in MTRR, but I have five and I am on a methylation protocol. You have two BHMT heterozygote mutations, I have for example 4 homozygotes.
I don't know how much effect these mutations have on any one individual. The combinations are endless and no doubt far beyond the few that we know about. I don't think you can do a simple comparison like I have 4 you only have 2 therefore you won't be as affected. It would certainly simplify things if it did work that way. Although MTRR polymorphisms need addressing I haven't heard that they are related to tolerance for methyl donors.
Your homozygote COMT can be a cause for concern with have excess catecholamine levels based on stress response or high methylation but you have to find your own balance on that. People who tend to be awash in catecholamines anyways or have high inflammation from the outset may have rougher time starting methylation treatment. But it still has to be done. You have to find your balance and get through it.
Perhaps a baseline check pre-support of your methylation pathway elements is in order, a la Doctor's Data or HDRI.
I wish! Money is a scarce resource and I do not have a doctor who is keen to test more than the most basic of options.
Maybe your methylation status is better than you realize. What symptoms do you attribute to poor methylation or low mb12?
Maybe it is, maybe it isn't. Everything is a shot in the dark when you can't afford a lot of testing and don't have access to a helpful doctor. 23andme testing seemed like a reasonable outlay to see what polymorphisms I have. I have not been able to tolerate more than a few days of a vitamin B multi. Initially I get an increase in energy, followed by extreme irritability, wired but tired and insomnia. It would be nice to know whether this means it is good for me or bad for me, or whether it means folate is the missing link.
I am very new to this and trying to avoid as many pitfalls as I can.