linusbert
Senior Member
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originally i was prescribed Pioglitazon (also known as Actos) for my then arrising diabetes, but i learned soon that it actually improves my "cfs"-like disease a lot. despite also changing all blood markers to the better. i become much more exercise tolerant.
now after my diabetes is getting really good after changing my bread and vitamin D, i removed insulin completely and i am still in 5,6% a1c range. now i want to get rid of Pioglitazon because it has nasty effects and its not even long term studied. I suspect it to be responsible for my decline in GFR.
i changed from 30mg to 15mg and want to get down to at least 7,5 if i cannot get off completely (7,5 for diabetes is as effective as 30mg...), and while my sugar even did improve after that even more, my cfs-like symptoms are getting worse again. its only been approx 1,5 weeks since doing that, i still hope my body does adapt to new situation and it stabilizes.
pioglitazone works strongly on PPARy and is somewhat anabolic. but despite metformin which immediately makes me get into PEM and crash after just one day of low dose, this pio stuff turns some switches in my body for the better, or at least so it feels.
more on PPARy: https://en.wikipedia.org/wiki/PPAR_agonist
i wonder what natural things can have the same effect?
EDIT: thats what chatgpt ai has to say about it:
https://www.sciencedirect.com/science/article/pii/S0006295214004249
now after my diabetes is getting really good after changing my bread and vitamin D, i removed insulin completely and i am still in 5,6% a1c range. now i want to get rid of Pioglitazon because it has nasty effects and its not even long term studied. I suspect it to be responsible for my decline in GFR.
i changed from 30mg to 15mg and want to get down to at least 7,5 if i cannot get off completely (7,5 for diabetes is as effective as 30mg...), and while my sugar even did improve after that even more, my cfs-like symptoms are getting worse again. its only been approx 1,5 weeks since doing that, i still hope my body does adapt to new situation and it stabilizes.
pioglitazone works strongly on PPARy and is somewhat anabolic. but despite metformin which immediately makes me get into PEM and crash after just one day of low dose, this pio stuff turns some switches in my body for the better, or at least so it feels.
more on PPARy: https://en.wikipedia.org/wiki/PPAR_agonist
i wonder what natural things can have the same effect?
EDIT: thats what chatgpt ai has to say about it:
PPARγ (peroxisome proliferator-activated receptor gamma) is a nuclear receptor that plays a crucial role in the regulation of various metabolic processes, including adipogenesis (formation of fat cells) and insulin sensitivity. Natural PPARγ activators are compounds found in nature that can stimulate the activity of PPARγ. Some of these natural activators include:
- Thiazolidinediones (TZDs): While not found directly in nature, certain pharmaceutical drugs like pioglitazone and rosiglitazone are synthetic PPARγ activators and are used in the treatment of type 2 diabetes.
- Fatty acids and their derivatives: Certain fatty acids, particularly polyunsaturated fatty acids (PUFAs) such as linoleic acid and eicosapentaenoic acid (EPA), can activate PPARγ. Additionally, certain prostaglandins derived from arachidonic acid can also act as PPARγ activators.
- Oleic acid: Found in olive oil, oleic acid is a monounsaturated fatty acid that has been reported to activate PPARγ.
- Flavonoids: Some flavonoids, which are plant-derived polyphenolic compounds, have been shown to activate PPARγ. Examples include quercetin, kaempferol, and apigenin, which are found in fruits, vegetables, and beverages like tea.
- Resveratrol: Found in red wine, grapes, and berries, resveratrol is a polyphenol that has been reported to have PPARγ-activating properties.
- Curcumin: A compound found in turmeric, curcumin has anti-inflammatory and antioxidant properties and has been reported to activate PPARγ.
- Lycopene: Found in tomatoes and other red fruits, lycopene is a carotenoid that may have PPARγ-activating properties.
- Berberine: Derived from various plants, including berberis species, berberine has been studied for its potential to activate PPARγ and improve insulin sensitivity.
https://www.sciencedirect.com/science/article/pii/S0006295214004249
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