Yes. I have gotten it for alpha adrenergic and muscarinic antibodies causing my hyper POTS and autoimmune MCAS. I was on autoimmune dose IVIG for about 20 months prior to beginning it and I have stayed on it throughout the treatment. My doctor also was very careful to ensure that I didn't have any active infections, which could have been part of the problem with some of the people who had bad experiences with Rituximab.
Several of his patients over the past 6 years have had success with this treatment. One does an initial infusion, then two weeks later a second infusion to kill all of the antibodies (B cells). Then, every 3 months for a year the dose is repeated. Then depending on how many and how bad the antibodies were to start with one can either continue for a little bit longer, or stop, and wait for the new B cells to grow back, which generally takes 6 to 12 months. And then you see if you have bad antibodies again. In most patients he's done it with that have had success, they have stayed away, if they've started to come back, then more or Rituximab is administered.
My doctor encouraged me to talk to some other patients who had gone through this process, and every one of them, whether it was successful or not was not sorry that they had done it. And, as the majority of my symptoms were due to my autoimmune problems, and I had had cytokine testing that indicated that they were totally autoimmune and not from infections, it seemed worth it to try.
Not wanting to be talked into such a major step by just one doctor, though I do trust him completely, I did get a second opinion from an immunologist in another city who is an expert at co-occurring immunodeficiency and autoimmunity, and we talked through various options, including stem cells and bortezimub, and he thought Rituximab would be my lowest risk, best chance of success choice. When I asked what protocol of it he recommended, he specified the exact same protocol, dose and timing, that my doctor had recommended. So I proceeded.
As I mentioned, it is very important to ensure that one has no infections before one wipes out all of one's antibodies. I did get a virus soon after my second infusion, and I was pretty ill for a month, but I finally kicked it with the help of IVIG, and after that everything has been fine. I have no B cells now, and I'm waiting for a few more months to see what happens.