Emphasis to alternative co-factor nutrients added by me. What is your experience with those?
Ubiquinol (Q10 in its active form) was very effective at first when I started taking it years ago but nowadays I don't notice anything even from big doses. I can take thiamine when I combine it with vitamin B2 in its active form. Otherwise I get the sulfur symptoms so there is a connection there. I haven't noticed anything when I take magnesium, zinc or choline. I still take magnesium daily. Zinc seems to cause constipation so I try to get it from food.
This is offtopic but I developed GERD in March. It is terrible to have GERD with CFS/ME and I don't respond all that well to PPI:s. Pepcid (famotidine) worked at first but it is losing its effectivenes. It sucks when having CFS/ME and you can't even sleep at night because of constant intestinal symptoms like constant bloating and belching and acid shooting straight to my throat and even ears. I get constant adrenaline rushes also because of this that keeps me awake. I think there is vagus nerve connection there.
I fixed my diet and realised that high FODMAP foods are triggers for me. I don't get much heartburn when I don't consume them but all the other symptoms still remain. Probably Candida and/or SIBO is causing all this and there may be the sulfur and poor detoxification connection to all this.
I tried betaine HCL and apple cider vinegar tablets but they both made my GERD symptoms even worse. Taking apple cider vinegar tablet was like dropping a mentos tablet into Coca Cola bottle.