My six year old grandaugter: her elbows bend backwards and backward sideways. This freaks out her Grandmother (thats me).
Sorry rufous. Not meaning to freak you out.
It freaks ne out to be honest because it's such a basic part of our well being.
Dint forget tgo, just because she's hypermobile, doesn't mean it immediately means cfs or anxiety. . I think ive said before Usain bolt has a hypermobile spine.
It depends how the connective tissue is spread throughout the body and brain. That's my belief.
I really think we need to triple down as a community to studying connective tissue.
Sure , there will be other complexities but I truly believe it's the root cause to predispose you to the disease process in m.e.
I think the good thing us regenerative medicine and specifically crispr will restore any issues your granddaughter may face ( which are obviously still hypothetical) as well as hopefully us.
What's strange is that heds has no genetic markers yet i believe . But there has to be.
Once crispr has learned how to cure more than single gene diseases and the genes for heds are identified then you're in the business of curing the disease.
Of course, any bridging therapy is totally welcome . And I'm sure we will get them.
Maybe even a functional cure.
So sorry to worry you rufous. But I think tgeres reason to hope too.