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my results (bad methylator?)

boo85

Senior Member
Messages
178
Hi there. Basically this year I've had a real hard time with low B12. So I can just take a B12 supplement and it will be ok? Nope. I react really strongly to B12. I just can't take it, not even low amounts (30mcg) in tablet form. It makes me anxious, paranoid, depressed. It's just really bad news for me mentally. If anyone could shed some light onto whether I'm a good/bad methylator or not, I'd really appreciate it.

Gene & Variation rsID Alleles Result
COMT V158M rs4680 AA +/+
COMT H62H rs4633 TT +/+
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 CC -/-
VDR Taq rs731236 AA +/+
MAO-A R297R rs6323 TT +/+
ACAT1-02 rs3741049 GG -/-
MTHFR C677T rs1801133 AA +/+
MTHFR 03 P39P rs2066470 GG -/-
MTHFR A1298C rs1801131 TT -/-
MTR A2756G rs1805087 AG +/-
MTRR A66G rs1801394 GG +/+
MTRR H595Y rs10380 CC -/-
MTRR K350A rs162036 AA -/-
MTRR R415T rs2287780 CC -/-
MTRR A664A rs1802059 GG -/-
BHMT-02 rs567754 CC -/-
BHMT-04 rs617219 AA -/-
BHMT-08 rs651852 CT +/-
AHCY-01 rs819147 TT -/-
AHCY-02 rs819134 AA -/-
AHCY-19 rs819171 TT -/-
CBS C699T rs234706 AG +/-
CBS A360A rs1801181 AG +/-
CBS N212N rs2298758 GG -/-
SHMT1 C1420T rs1979277 GG -/-
 

Critterina

Senior Member
Messages
1,238
Location
Arizona, USA
boo85,

There are several results you posted that suggest you might not tolerate methyl groups well - which is just what you report: anxious, paranoid, depressed. I'm guessing you tried methylcobalamin. You might try hydroxocobalamin, which is a different form of B12. There's also cyanoB12 and AdenosylB12, but I would try the hydroxoB12 (or hydroxyB12) first. I think it's your best bet.
 

Valentijn

Senior Member
Messages
15,786
boo85
MTHFR C677T can cause a really big problem with creating methylfolate - basically running at 30% the normal rate. Supplementing methylfolate is probably necessary.
 

Critterina

Senior Member
Messages
1,238
Location
Arizona, USA
boo85
MTHFR C677T can cause a really big problem with creating methylfolate - basically running at 30% the normal rate. Supplementing methylfolate is probably necessary.
Valentijn,
Boo is also MTRR A66G rs1801394 GG +/+, so that will be running slower, too, right? And I bet you know about how slow. :). Do you think that supplementing with B12 is causing her to use up all her methylfolate, and that's what's making her feel so bad?
If anyone could shed some light onto whether I'm a good/bad methylator or not, I'd really appreciate it.
Boo,

Between MTHFR C677T rs1801133 AA +/+ and MTRR A66G rs1801394 GG +/+you're going to be a "bad" (I would say ineffiecient) methylator.

Then you add BHMT-08 rs651852 CT +/-, which is the second (I think of it as a backup) method for converting homocysteine back to methionine, and that's not working full speed either.

Do you have test results for serum homocysteine? B6 or a serum amino acid profile? Urine sulfur? Serum ammonia?

Let me ask if you have tried these supplements and how you reacted. I am NOT recommending that you systematically go and try them:

methylfolate (with or without methylB12 at the same time)
P5P
5-HTP
TMG or SAMe (Definitely not recommending those)
NAC
Alpha lipoic acid

I'm not sure any of this will shed light on why you react to B12 that way, but it might. You've got me wondering...
 

Valentijn

Senior Member
Messages
15,786
Valentijn,
Boo is also MTRR A66G rs1801394 GG +/+, so that will be running slower, too, right? And I bet you know about how slow. :). Do you think that supplementing with B12 is causing her to use up all her methylfolate, and that's what's making her feel so bad?
The MTRR A66G mutation means that you need to produce 3-4x as much MTRR to recycle MTR at a normal rate. B12 is supposed to help keep the recycling process going in the right direction.

I'm not sure if those problems would cause methylfolate to be used up and result in poor B12 tolerance, but regardless, methylfolate supplementation is probably needed. So it's definitely worthwhile to supplement methylfolate for a bit before trying the B12 again, or trying both together.