JES
Senior Member
- Messages
- 1,374
You don't need to go off topic here, we are well capable of reading your thread. I once again highlight that this forum has 45(!) threads on thiamine and in fact some very recent ones other than yours as well, which you can find using search (link). Have you read those?I really don't care if I annoy people by "spreading this info", but people need to make the final connection.
I have and the conclusion is pretty clear. There is no evidence of ME/CFS patients having any kind of clinical thiamine deficiency. I suspect thiamine could work temporary in way of addressing some metabolic pathway dysfunction, for example in the enzyme pyruvate dehydrogenase that requires thiamine to convert from pyruvate to Acetyl-CoA. Because these pathways are dysregulated in ME/CFS rather than broken due to some inherited metabolic defect, adding one metabolic co-factor supplement to our stack is unlikely to solve much for most of us. Here is an article that speculates thiamine could work as some sort of metabolic stimulant. Interesting, but again my concern as with other stimulants as it that the effect is lost over time.
Moreover, people here (I dare speak for most) aren't new to supplements. Something as basic as thiamine would have come up early in our treatment experiments. If you come up with something that is not already commonly promoted by the supplement industry, it is more likely we would not have paid attention or tried it yet.