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The results obtained indicate that the combination of nucleoside analogs zidovudine and dideoxyinosine with the protease inhibitor indinavir effectively inhibits MLV-derived RCR replication in three human cell lines.
Inhibitors designed against HIV-1 PR were also active on MLV PR,
although all of the tested ones were substantially less potent on this enzyme than on HIV-1 PR.
Nevertheless, amprenavir, the most potent inhibitor against MLV PR, was also able to block
Gag processing in MLV-infected cells.