MTHFR, Normal Homocysteine, and Cardiovascular issues

[suzievv]

If someone is MTHFR homozygous 677 (two copies of C677T), and their homocysteine level is normal, can MTHFR still cause cardiovascular problems? If so, HOW??

My parents and I are all homozygous 677. My dad had an occasional rapid heartbeat for decades; I had a large blood clot on my placenta during a recent pregnancy; and my mom has a huge blockage in an artery in front of her heart that is requiring open heart bypass surgery. We all have very normal homocysteine, eat healthy and have healthy weights. I don't think doctors will say there's a connection with MTHFR. Maybe I'm jumping to conclusions, but I can't help but wonder if there is a connection.

This is my first post here at Phoenix Rising, and I have seen that many people here seem to be very knowledgeable about MTHFR.

 

[shah78]

The "tests" are pretty useless imho. My homocysteine , B12 and mma were all smack dab in the middle of normal, so my intergrative NP never mentioned a b12/folate trial. Wasted four years of recovery. And this was a fairly, way out clinic. I can imagine how a "SURGEON" would react to a "crazy" idea like Genetics. Run away as quick as you can!!!

 

[taniaaust1]

I know my specialist told me that the risk of strokes goes up as the homoeocysteine does and tended to think we were safer if on the right supplements.

I do think thou anyone with MTHFRC667T should take this issue seriously and supplement for it. I have a disabled child (very rare condition but similar to spinia bifida) all due to this mutation and not knowing I had it so I took the wrong for of folate during pregnancy.