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Monoclonal antibodies

Hip

Senior Member
Messages
17,995
This looks like it could end up as a future therapy for chronic fatigue syndrome:

Monoclonal antibodies: short-term therapy for the long-term treatment of chronic viral infections?

From the 4th paragraph of the above link:

...under certain conditions, a very short course of treatment (a few days) with antiviral monoclonal antibodies can have an additional effect similar to that of a vaccine. After three weeks, and even though the injected monoclonal antibodies had disappeared, the researchers indeed detected a potent and long-lasting (more than a year) antiviral immune response...
 

glenp

"and this too shall pass"
Messages
776
Location
Vancouver Canada suburbs
Very interesting!! I have often wondered what triggered good days that I used to have. I wonder if it could be antibodies?
I hope they do something with this soon.

glen
 
Messages
18
Yes, RItuximab (Mabthera) is one of them and is used in trials by Norway scientists to treat CFS. Actually, they must have finished their latest trial, but I don't see the results are out yet.
 

redo

Senior Member
Messages
874
Quote: "After three weeks, and even though the injected monoclonal antibodies had disappeared, the researchers indeed detected a potent and long-lasting (more than a year) antiviral immune response (...)"

"In mice, a short and early course of therapeutic monoclonal antibodies targeting both the viruses and the cells infected by these viruses thus enables permanent recovery from a fatal chronic infection."

Rituximab is a monoclonal antibody. And in a small trial it has given a strong temporary symptom relief lasting for over a month in 3/3 patients.

Perhaps monoclonal antibodies work even better if the person have received or is receiving ARV at the same time. Just a though...
 

mojoey

Senior Member
Messages
1,213
One of the abstracts presented at the NIH conference talked about TSG101 as being a protein that was expressed on every cell infected with a retrovirus. It also discussed the possible therapy of using monoclonal antibodies that target TSG101.
 
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