Momentary switch of state

[linusbert]

Apologies if this is unclear. I’m a bit tired today.

thanks, actually this is quite understandable

 

[kushami]

I should add that vasodilators are usually contraindicated for anyone with classical orthostatic intolerance, in which the problem is that not enough blood makes it to the head when you are upright. Many people with CFS have this type of blood flow problem. If you find that increasing blood volume (e.g. more salt and water) or giving your blood a boost towards the head (e.g. compression garments) help, then you probably have classical OI.

The problem in hypertensive-type OCHOS is that although a normal amount of blood gets to the head not enough of it can get in because it can’t get past the abnormal vasoconstriction. A smaller number of people with CFS probably have this, although I haven’t seen anything published to confirm it. If you have noticed that you feel better on any kind of vasodilator, you might be in this category.

I see that Prof Novak gave a talk at the recent conference, so he might have more to reveal on this topic. His talk hasn’t been released yet. Dr Systrom’s talks are up, and he would be speaking on this topic too, probably more on the classical OI side.

International ME/CFS Conference 2025 thread:
https://forums.phoenixrising.me/threads/international-me-cfs-conference-2025-videos.93457/

 

[JES]

It's a real pain. I used to have this "hyperadrenergic form" in which vasoconstriction was dominant. Trying to "hack" this with drugs or supplements that would directly affect it, I only ended up with either too much vasoconstriction or too little. With certain beta blockers and mestinon the end result was too much vasodilation.

Trying to reduce the inflammation and modulating the immune system was the only thing that ended up helping for me.