you have any research links to this
Oh, I had always heard that these need to be taken together. Hmmmm. Thanks.
ACU-CELL:
Best time to take Vitamin D: Morning to afternoon; preferably with fatty food.
Vitamin D Synergists: Magnesium, boron, selenium*, Vitamin C, Vitamin E, lycopene, UV rays, Vitamin A*.
Vitamin D Antagonists / Inhibitors: Calcium, strontium, cadmium,
Vitamin K*, Vitamin A*, alcohol, mineral oil, oral steroids.
* Dose-dependent - They are co-factors at normal levels, and antagonists at higher levels.
Best time to take Vitamin K: Morning to afternoon; preferably with fatty food.
Best time to take :
Cellular / Intracellular Attributes and Interactions:
Vitamin K Synergists: Calcium, copper, Vitamin B5, flavonoids,
Vitamin D*. [Vitamin K protects against Vitamin D overdose].
Synergists:
Vitamin K Antagonists / Inhibitors: Vitamin A, Vitamin E, mineral oil, oxalates, alcohol, Coenzyme Q10, blood thinners / anticoagulants (coumadin), Antibiotics - by killing intestinal bacteria.
Antagonists / Inhibitors:
* Dose-dependent - They are co-factors at normal levels, and antagonists at higher levels.
DR. STEVEN LIN:
Take your Vitamin
K2 supplement with your dinner that includes dietary fat or at bedtime, 8 to 12 hours after you take your Vitamin
D3. Most people take their
D3 with breakfast and
K2 at dinner time and this seems sensible, as some research shows that
D3 is more effective if not taken at the same time as
K2.
CONSUMER LABS
However, evidence (mainly from animal and cell studies) suggests that moderate to large doses of fat-soluble vitamins reduce absorption of other fat-soluble vitamins - by about 10 to 50% - due to competition.
Absorption of vitamin K appears to be particularly reduced by other fat-soluble vitamins……. (which would include Vit D)
While there do not appear to be substantial numbers of studies demonstrating reduced Vit K absorption in human subjects due to Vit D,
it may be best to take Vit K at least 3 hours apart from Vit D, and not in combination “bone health” formulas which include Vit D. Keep in mind that such formulas are rarely clinically tested on human subjects for ingredient absorption, let alone for efficacy and safety.
A laboratory experiment using intestinal cells from mice found that uptake of Vit K was reduced by approximately half by Vitamins A, D, and E, likely due to competition for absorption among these fat-soluble vitamins (
Goncalves, Food Chem 2015)
MENAQUINONE-7 SUPPLEMENTATION TO REDUCE VASCULAR CALCIFICATION IN PATIENTS WITH CORONARY ARTERY DISEASE (NCBI, MC, 2015 Nov; 7
Inhibition of the vitamin-K-cycle by vitamin K antagonists (VKA) results in the accumulation of uncarboxylated MGP which is biologically inactive. This is associated with extensive arterial calcification in experimental animals [
5,
8]. In line with the experimental data, humans on VKA treatment also tend to have more aortic and valve calcification in comparison to patients not on anticoagulant therapy.
As an aside, and from my own personal experience, Vitamin D doses will also inhibit or halt the production of melatonin, so it might also be wise to take Vitamin D with an earlier meal than dinner if you have problems with insomnia. I take mine with breakfast in order not to add anything more to the misery of the well-established insomnia effects experienced by so many of us here.
EDIT: For really wretched typing skills and impaired brain function.
