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Microglia LPS inflammatory cytokines and Pycnogenol

knackers323

Senior Member
Messages
1,625
Ive known for a while that taking large amount of Pycnogenol greatly improves how I feel.

I'm not sure of the mechanism as it apparently does so many things but the effect begins within hours and is cumulative.

Id say it is to do with inflammation. Not sure if its a good idea to take such large amounts longterm. But I feel much better right now.
Rec dose is 1-2 tab daily. Today ive taken about 40 and about 20 yesterday.
Maybe not a good idea but worth a trial.
Anyone else tried it?

This link is interesting

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569068/
 

pattismith

Senior Member
Messages
3,926
Ive known for a while that taking large amount of Pycnogenol greatly improves how I feel.

I'm not sure of the mechanism as it apparently does so many things but the effect begins within hours and is cumulative.

Id say it is to do with inflammation. Not sure if its a good idea to take such large amounts longterm. But I feel much better right now.
Rec dose is 1-2 tab daily. Today ive taken about 40 and about 20 yesterday.
Maybe not a good idea but worth a trial.
Anyone else tried it?

This link is interesting

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569068/

That's nice, and it's a french pine extract, I should give it a try!:)

Maybe @Hip will want to add it to his list of microglial inhibitors:

http://forums.phoenixrising.me/inde...-treatment-using-microglial-inhibitors.34164/
 

alex3619

Senior Member
Messages
13,810
Location
Logan, Queensland, Australia
I experimented with this in the early days when it first became available in Australia. I was using the grape extract version imported from France. I took four tabs the first time. Nothing for a minute or five. Wait, was my stomach fizzing? Then moving out till via the circulation to everywhere. The fizzing became very very intense. It was like someone had replaced all my blood with soda. Then the fizzing faded, after about half an hour, and I felt very very good.

Sadly this was the only time this worked for me.

Too many antioxidants might not be a good idea as they can disrupt metabolism. I wonder if periods on pycnogenol and off pycnogenol might be better.
 
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Learner1

Senior Member
Messages
6,305
Location
Pacific Northwest
Balancing antioxidants is best. Too much of any one can lead to problems.

"The Antioxidant Miracle" by Lester Packer, who ran the world's foremost antioxidant lab at UC Berkeley for many years explains the general principles of the antioxidant network.
 

alex3619

Senior Member
Messages
13,810
Location
Logan, Queensland, Australia
Balancing antioxidants is best. Too much of any one can lead to problems.

"The Antioxidant Miracle" by Lester Packer, who ran the world's foremost antioxidant lab at UC Berkeley for many years explains the general principles of the antioxidant network.
I have read this book and what it says about how the five core antioxidants work is probably right, though I did not investigate much. Further its an issue that many metabolic processes require free radicals. If they are quashed too fast it can be a problem. However the use of pycnogenol may be for more than just antioxidant status, and different antioxidants have different optimal targets. Plant antioxidants may work really well in some cases, whereas normal human antioxidants may not. We still do not know enough.

The usual dosage of Resveratrol which I use a lot is about 300mg per day. I take 600 mg, but no more than twice a week, and not even that these days. The issue here is that the response can be different at different doses, presumably because it triggers state changes in the body. Indeed the reason I tried pycnogenol at a higher dose was that its impact on nitrosative stress is variable at different doses, at least according to some paper I read way back then (this was a decade or two back, and I do not recall details).

My point is that sometimes there is a threshold effect, though it may vary person to person, and over time. A brief antioxidant burst might well trigger physiological change. What we do not know is if that can be permanent, or sustained with repeated use. Nor do we know if prolonged use of antioxidants like this might be dangerous, or in what way.
 
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Wishful

Senior Member
Messages
5,644
Location
Alberta
Antioxidants seem to have the opposite effect for me: they make me feel worse. Peroxynitrite scavengers do the same. However it may be that the antioxidants I've tried also have peroxynitrite scavenging effects too. I haven't done an exhaustive search for an antioxidant that doesn't noticeably reduce peroxynitrite levels, so I can't test that yet.
 

ljimbo423

Senior Member
Messages
4,705
Location
United States, New Hampshire
Ive known for a while that taking large amount of Pycnogenol greatly improves how I feel.

I'm not sure of the mechanism as it apparently does so many things but the effect begins within hours and is cumulative.

Id say it is to do with inflammation. Not sure if its a good idea to take such large amounts longterm. But I feel much better right now.
Rec dose is 1-2 tab daily. Today ive taken about 40 and about 20 yesterday.
Maybe not a good idea but worth a trial.
Anyone else tried it?

This link is interesting

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569068/

Curcumin is a very powerful anti-inflammatory and can be safely taken in very large doses, like 2-3 grams a day or more.

I started taking it several days ago and have noticed more clarity of mind, better energy, a lessening of allergy symptoms and it just feels like I have less inflammation throughout my body. I also feel calmer it seems.

I also added in omega 3's (dha/epa) and ginger in the last couple of days. They are both anti-inflammatory as well.

Jim
 

Gondwanaland

Senior Member
Messages
5,092
I feel that plant antioxidants tend to be too adstringent and deplete fat-soluble vitamins.

I also feel that omega 3 can be overdone and then the adrenals will need omega 6.
 

Learner1

Senior Member
Messages
6,305
Location
Pacific Northwest
Curcumin is a very powerful anti-inflammatory and can be safely taken in very large doses, like 2-3 grams a day or more.

I started taking it several days ago and have noticed more clarity of mind, better energy, a lessening of allergy symptoms and it just feels like I have less inflammation throughout my body. I also feel calmer it seems.
I've taken up to 6g of curcumin orally as well as 50-100g in IV form to reduce brain inflammation from IVIG treatment. It's been very helpful.
I also added in omega 3's (dha/epa) and ginger in the last couple of days. They are both anti-inflammatory as well.

Jim
Boswellia is good, too.
 

Gondwanaland

Senior Member
Messages
5,092
The usual dosage of Resveratrol which I use a lot is about 300mg per day. I take 600 mg,
How do you evaluate the blood thinning effect on fatigue? Anything that requeires more blood thinning action from my liver causes me increased fatigue.
but no more than twice a week, and not even that these days.
I never tolerated Resveratrol, I think because I am deficient in fat-soluble vitamins and it is too adstringent. I am looking for a non-adstringent blood thinner, I suppose CoQ10 would be good?
 

physicsstudent13

Senior Member
Messages
611
Location
US
I have NAFLD and hemangioma and very impaired liver function. I've read resveratrol can help NAFLD and liver disease. does anyone have evidence that this is true?