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https://www.cell.com/neuron/fulltext/S0896-6273(18)31009-2
Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder
Highlights
Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder
- Martina Sgritta
- Sean W. Dooling
- Shelly A. Buffington
- Michael B. Francis
- Robert A. Britton
- Mauro Costa-Mattioli 6
Highlights
- •
Treatment with L. reuteri rescues social deficits in several ASD mouse models - •
L. reuteri reverses social deficits via the vagus nerve - •
L. reuteri reverses social deficits even in germ-free mice - •
OXTR inhibition prevents L. reuteri’s effects on social behavior and VTA plasticity