mariovitali
Senior Member
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This is a proposed new Research target for ME/CFS. MFGE8 is Milk Fat Globule-EGF factor 8 Protein also known as Lactadherin.
CC : @Hip @JaimeS
Here are some excerpts :
Intestinal Epithelium Integrity :
Inflammatory Disease :
Sepsis:
Original text :
http://algogenomics.blogspot.com/2018/05/milk-fat-globule-membrane-mfgm.html
CC : @Hip @JaimeS
Here are some excerpts :
Milk fat globule membrane (MFGM) is a complex and unique structure composed primarily of lipids and proteins that surrounds milk fat globule secreted from the milk producing cells of humans and other mammals. It is a source of multiple bioactive compounds, including phospholipids, glycolipids, glycoproteins, and carbohydrates that have important functional roles within the brain and gut.
Intestinal Epithelium Integrity :
The intestinal epithelium is a continuous single layer of cells that lines the intestinal tract. It provides a physical barrier that separates internal body compartments and the harmful environment of the gut lumen. Defects in epithelial barrier and immune functions can lead to infections with opportunistic and pathogenic microbes and contribute to the pathogenesis of inflammatory bowel disease (IBD). Recent studies have shown that macrophages in the underlying intestinal tissue produce milk fat globule-EGF factor 8 (MFG-E8) which directly targets intestinal epithelial cells and regulates the integrity of intestinal epithelial barrier function.
Inflammatory Disease :
Some studies have demonstrated that MFG-E8 plays a role in inflammatory degenerative bone diseases such as RA and osteoarthritis (OA). The expression of MFG-E8 is downregulated in inflammatory conditions and has also been found to be downregulated in the sera of RA patients, while an in vitro study revealed that MFG-E8 suppresses inflammatory responses by suppressing the production of proinflammatory cytokines. Moreover, the expression of MFG-E8 is decreased in arthritic mice, and the loss of MFG-E8 exacerbated arthritis and led to more severe bone loss in mice by inducing the production of proinflammatory cytokines and the infiltration of pathogenic neutrophils in the inflamed joints
Sepsis:
Sepsis is a high lethal systemic inflammatory disease characterized by the increase in proinflammatory cytokines and the accumulation of apoptotic cells. It has been reported that MFG-E8 is correlated with sepsis. During sepsis, a large number of immune cells undergo apoptosis due to the impairment of apoptotic cell clearance, which then induces secondary necrotic cell development that dysregulates proper immune function and induces the production of proinflammatory cytokines. Therefore, studying the function of MFG-E8 could lead to promising therapeutic approaches that facilitate the clearance of apoptotic cells by MFG-E8 in sepsis.
Original text :
http://algogenomics.blogspot.com/2018/05/milk-fat-globule-membrane-mfgm.html