Methionine benefit my face skin, how?

[jason30]

Hi all,
When I take methionine powder then within 2 hours my face skin gets better. Much cleaner and better look, not puffy.
Unfortunately I had to stop with methionine because of the over-methylation symptoms, but I wonder how methionine have a positive effect on my face skin?

Thanks in advance for thinking along.

 

[linusbert]

methionine fills a place in many important areas in your body, one is methylation.
regarding your overmethylation, try to take glycine, its buffer for methyl groups.

grok says about this:

Spoiler

One possibility is methionine’s role in collagen production. Methionine is a sulfur-containing amino acid, and sulfur is a key component of cysteine, which is needed to form collagen—a protein that keeps skin firm, elastic, and hydrated. When you took methionine, it might have supported collagen synthesis, leading to that cleaner, less puffy look you noticed. Reduced puffiness could also tie into better fluid balance in your skin, possibly influenced by improved protein structure.
Another angle is detoxification. Methionine is a precursor to glutathione, a powerful antioxidant that helps clear out toxins and reduce oxidative stress. If your skin was dealing with inflammation or damage from free radicals, the boost in glutathione production could have calmed things down, giving your face that clearer, healthier appearance.
The timing—within 2 hours—suggests something fairly direct. It might not be the full metabolic pathway (which takes longer) but could be related to methionine’s involvement in supporting blood flow or reducing inflammation quickly. For example, methionine contributes to the production of S-adenosylmethionine (SAMe), which has anti-inflammatory properties and could subtly improve skin tone or reduce puffiness in the short term.
As for the over-methylation symptoms that made you stop, that’s likely because methionine feeds into the methylation cycle. Too much can overstimulate it, leading to side effects like anxiety or irritability for some people. It’s a bummer you had to stop, but it’s cool you picked up on that connection.

 

[andyguitar]

but I wonder how methionine have a positive effect on my face skin?

Helps skin to retain moisture.

 

[GhostGum]

I always thought it was a big part of the basis of all cellular function/repair, so it is going to be basically helping to restore all tissue, and part of the reason why protein intake is so vital just to maintain your literal biology and physical structure, maybe more so as you age.

I can actually tell a lot of the time how well I am doing based on how well my skin is doing, when I actually feel comfortable in my own skin, which is not often, have good circulation and am relaxed I can start to resemble a 'normal' human being and have a healthier glow. When I am not doing well I am more anaemic, dry skin, uncomfortable, poorer circulation and can even appear to be more aged in the hands and feet.

 

[linusbert]

i guess i need to give my today shrimpy hands a protein treatment... eggs it is for dinner

 

[jason30]

methionine fills a place in many important areas in your body, one is methylation.
regarding your overmethylation, try to take glycine, its buffer for methyl groups.

grok says about this:

Spoiler

One possibility is methionine’s role in collagen production. Methionine is a sulfur-containing amino acid, and sulfur is a key component of cysteine, which is needed to form collagen—a protein that keeps skin firm, elastic, and hydrated. When you took methionine, it might have supported collagen synthesis, leading to that cleaner, less puffy look you noticed. Reduced puffiness could also tie into better fluid balance in your skin, possibly influenced by improved protein structure.
Another angle is detoxification. Methionine is a precursor to glutathione, a powerful antioxidant that helps clear out toxins and reduce oxidative stress. If your skin was dealing with inflammation or damage from free radicals, the boost in glutathione production could have calmed things down, giving your face that clearer, healthier appearance.
The timing—within 2 hours—suggests something fairly direct. It might not be the full metabolic pathway (which takes longer) but could be related to methionine’s involvement in supporting blood flow or reducing inflammation quickly. For example, methionine contributes to the production of S-adenosylmethionine (SAMe), which has anti-inflammatory properties and could subtly improve skin tone or reduce puffiness in the short term.
As for the over-methylation symptoms that made you stop, that’s likely because methionine feeds into the methylation cycle. Too much can overstimulate it, leading to side effects like anxiety or irritability for some people. It’s a bummer you had to stop, but it’s cool you picked up on that connection.

Thanks a lot, that give some great insights. I am curious to try collagen separately to check if that benefit my skin, will order some.
Do you by change know if you can determine if the skin is dealing with inflammation? Because there is nothing special to see in the face (no redness etc).

 

[jason30]

Helps skin to retain moisture.

Interesting! I do have a dry skin at this moment (mostly in the winter).
Thanks.

 

[jason30]

I always thought it was a big part of the basis of all cellular function/repair, so it is going to be basically helping to restore all tissue, and part of the reason why protein intake is so vital just to maintain your literal biology and physical structure, maybe more so as you age.

I can actually tell a lot of the time how well I am doing based on how well my skin is doing, when I actually feel comfortable in my own skin, which is not often, have good circulation and am relaxed I can start to resemble a 'normal' human being and have a healthier glow. When I am not doing well I am more anaemic, dry skin, uncomfortable, poorer circulation and can even appear to be more aged in the hands and feet.

I notice that as well, my skin gets affected very quickly (little stress etc).
Do you take extra proteins besides your food intake? Like whey?

 

[linusbert]

Do you by change know if you can determine if the skin is dealing with inflammation? Because there is nothing special to see in the face (no redness etc).

i dont know, if its not red or has any visible signs i dont know how you would find out. but my guess is , if the skin is fine there is probably no inflammation.
but the skin is thick and not everything must be in upper layers. but also beneath i would expect some sort of sign like fluid retention, pain or so.

 

[jason30]

i dont know, if its not red or has any visible signs i dont know how you would find out. but my guess is , if the skin is fine there is probably no inflammation.
but the skin is thick and not everything must be in upper layers. but also beneath i would expect some sort of sign like fluid retention, pain or so.

Thanks, then my guess it's not inflammation.

I do benefit from antibacterial sups, they give me a much better skin as well. I am stil figure out why antibacterial is giving me a better skin. The effect of an antibacterial is visible after a few days, some on the same day after a few hours.
I read that methionine is not an antibacterial but it is anti-biofilm; "research shown to inhibit and disassemble Pseudomonas biofilms at low concentrations (link)."
Interesting!

 

[linusbert]

antibacterial

also almost anything in concentrated dose is antibacterial or even antimicrobial.
sugar or salt for example are used to make meat and other food be good much longer.
so it might not be the antimicrobial factor at all which makes you feel better. could be another physiological reason.
if you want something hard against biofilms look into serrapeptase. also its anti inflammatory.

 

[GhostGum]

I notice that as well, my skin gets affected very quickly (little stress etc).
Do you take extra proteins besides your food intake? Like whey?

I do use whey every morning in a smoothie for that initial 30g protein and amino intake.

When you say stress this seems to my case as well, even the slightest stuff seems to throw my system out which leads to impacts on skin, structural tension and postural issues, muscle weakness and inactivation, which all impacts circulation as well. I have to be super disciplined in my pacing routines and trying to engage and active my body all day long without exertion, bumbling I tend to call it.

Could be I have still not worked out my diet properly though as well, possibly too much histamine still, and for an over-methylator maybe too much protein equals too much methionine which messes me up? Bit tired of it all tbh. I should probably work on though reasonably high protein and low histamine more, food management is just a pain.

 

[jason30]

also almost anything in concentrated dose is antibacterial or even antimicrobial.
sugar or salt for example are used to make meat and other food be good much longer.
so it might not be the antimicrobial factor at all which makes you feel better. could be another physiological reason.
if you want something hard against biofilms look into serrapeptase. also its anti inflammatory.

I have actually used serrapeptase years ago, it gave me also a lot of benefits. But it killed at that time too much which gave a (detox) load on the liver.

 

[jason30]

I do use whey every morning in a smoothie for that initial 30g protein and amino intake.

When you say stress this seems to my case as well, even the slightest stuff seems to throw my system out which leads to impacts on skin, structural tension and postural issues, muscle weakness and inactivation, which all impacts circulation as well. I have to be super disciplined in my pacing routines and trying to engage and active my body all day long without exertion, bumbling I tend to call it.

Could be I have still not worked out my diet properly though as well, possibly too much histamine still, and for an over-methylator maybe too much protein equals too much methionine which messes me up? Bit tired of it all tbh. I should probably work on though reasonably high protein and low histamine more, food management is just a pain.

I can relate to that, also have to be extra discplined in the routine.
Many whey contains a lot of methionine. I found a grass-fed whey that is more balanced which I am gonna give it a try;

This is Clearly Grass-fed whey

 

[linusbert]

sadly whey gives me allergy or histamine issues lately

 

[GhostGum]

I can relate to that, also have to be extra discplined in the routine.
Many whey contains a lot of methionine. I found a grass-fed whey that is more balanced which I am gonna give it a try;

This is worth a quick watch, I have known about the benefits of glycine but didn't know there was a connection to methionine and glycine specifically. Wondering if extra glycine can help negate the issues with too much methionine or over methylation? I know some people swear by it, I was using it for a while but should try again, and at a higher dose. It is very tolerable too due to how nice it tastes.

 

[jason30]

This is worth a quick watch, I have known about the benefits of glycine but didn't know there was a connection to methionine and glycine specifically. Wondering if extra glycine can help negate the issues with too much methionine or over methylation? I know some people swear by it, I was using it for a while but should try again, and at a higher dose. It is very tolerable too due to how nice it tastes.

Thanks a lot, checked the video and very interesting.

Unfortunately glycine gives me a lot of symptoms, this is because of the conversion to oxalates.
I still didn't figured it out how to stop this conversion to oxalates.

 

[GhostGum]

Thanks a lot, checked the video and very interesting.

Unfortunately glycine gives me a lot of symptoms, this is because of the conversion to oxalates.
I still didn't figured it out how to stop this conversion to oxalates.

I haven't heard that one, but am aware of the potential issue of excess NMDA activity and the potential for excitotoxicity, if you have high glycine and high glutamate which may not be clearing properly.

Issues with the SOD1 gene which I have, seem to also play a role in this, leading to more potential for glutamate toxicity due to extra oxidative stress interfering with glutamate transporters.

Kind of only just learning about this though too, with the help of AI a bit, but can't help but wonder whether this explains a lot of things for me over the years, excess NMDA activity and too much oxidative stress and or neuron burnout.

All so bloody complicated, back to trying to balance diet and some supplements I guess. But that could help explain issues with glycine.