Medicine getting stronger as we taper down to lower dose?

[SpinachHands]

This is an odd one, and more of a general medicine question than ME, but I know this forum is great at things like this.
My partner started Amantadine on 25mg and tapered up to 50mg, but started getting this feeling of it "overshooting" where they were benefitting, into feeling worse. We've been tapering down gradually (only 1-2mg at a time) but it feels like the medicine is getting stronger the lower they go. The most common side effects is low blood pressure, which they didn't get at 50mg, but have started getting now they're down at 20mg. If they go down by 2mg the overshoot effect does lessen, but then the same dose the next day it'll feel higher. It feels like a race, every time we try lowering it, it gets stronger to catch up. Any ideas why this is happening? We really want to find a dose of this that is workable, but just can't seem to get it low enough.

 

[linusbert]

could be what you experience could be something different, a accumulation effect that increases every day. a lot of medications work like this. some diabetes medications build up over weeks and months.
but dose dependent effects are also known, but i know not much about this. some meds seam to indeed to have different effects depending on the dose.