Here are some quotes from Ray Peat and selected studies about endotoxins.
http://www.functionalps.com/blog/2011/11/20/endotoxin-and-liver-health/
Of interest is:
"The liver serves as the key organ for the removal and detoxification of bacterial endotoxins that are continously absorbed in small amounts from the gastrointestinal tract. This paper postulates that liver injury impairs this detoxification process leading to further liver damage and systemic effects as well. Evidence is reviewed to support the contention that endotoxin may be a major common pathway for liver injury by a variety of agents, and methods of reducing endotoxicity of gut origin are proposed"
It's also interesting that endotoxins can interfere with glucose metabolism:
"These findings are consistent with down regulation of carbohydrate oxidation following LPS administration, which, based on the present data, may be due to PDC inactivation as a consequence of a rapid and marked increase in PDK4 mRNA and presumably protein expression."
http://www.physoc.org/proceedings/abstract/J Physiol 565PC99
So it seems that endotoxins stimulate the transcription of the enzyme that breaks down Pyruvate Dehydrogenase (PDK) and impair glucose oxidation.
If we assume that ME/CFS is a perpetual state of low-grade sepsis, PDH would appear to be inhibited in ME Blood studies, which it does!
The evidence keeps piling up...