ME/CFS is a mast cell disorder (hypothesis)
- Thread starter nanonug
- Start date
Well, mast cell activation/degranulation is responsible for allergic response, after all!
I have yes, with some success. Right now, however, I am preparing to do some of the mast cell related tests and I am therefore off of any drugs and supplements that might interfere. As a consequence, I have been very tired and with terrible brain fog.
I have yes, with some success. Right now, however, I am preparing to do some of the mast cell related tests and I am therefore off of any drugs and supplements that might interfere. As a consequence, I have been very tired and with terrible brain fog.
Some of them do, such as Gastrocrom, for instance. However, H1 and H2 blockers are generally available over the counter.
I was doing some research on licorice and stumbled across this research paper.
"""""""""
Isoliquiritigenin Selectively Inhibits H2 Histamine Receptor Signaling.
Dong-Chan Kim, Se-Young Choi, Sun-Hee Kim, Bong-Sik Yun, Ick-Dong Yoo,
Nanga. Ravi Prakash Reddy, Ho Sup Yoon, and Kyong-Tai Kim
accepted May 3, 2006
ABSTRACT
Isoliquiritigenin, one of the major constituents of Glycyrrhiza uralensis (licorice), is a natural pigment with a simple chalcone structure 4,2,4-trihydroxychalcone. In this study, isoliquiritigenin showed selective H2 histamine receptor (H2R) antagonistic effect and remarkably reduced several H2R-mediated physiological re- sponses. Preincubation of U937 and HL60 hematopoietic cells with isoliquiritigenin significantly inhibited H2R agonist-induced cAMP response in a concentration-dependent manner without affecting the viability of cells. Isoliquiritigenin also blocked the binding affinity of [3H]tiotidine to membrane receptors in HL-60 cells. Isoliquiritigenin did not affect the elevation of cAMP levels induced by cholera toxin, forskolin, or isoproterenol, indicatingthat the action site of isoliquiritigenin is not Gs protein, effector enzyme, adenylyl cyclase, or 2-adrenoceptor.
Isoliquiritigenin affected neither H1R- nor H3R-mediated signaling. In molecular docking studies, isoliquiritigenin exhibited more favorable interac- tions with H2R than histamine. Isoliquiritigenin prominently inhib- ited H2R selective agonist dimaprit-induced cAMP generation in MKN-45 gastric cancer cell. Moreover, isoliquiritigenin reduced gastric acid secretion and protected gastric mucosal lesion for- mation in pylorus-ligated rat model.
Taken together, the results demonstrate that isoliquiritigenin is an effective H2R antagonist and provides the basis for designing novel H2R antagonist.
"""""""
The entire Paper can be found here:
http://www.ncbi.nlm.nih.gov/pubmed/16675659
"""""""""
Isoliquiritigenin Selectively Inhibits H2 Histamine Receptor Signaling.
Dong-Chan Kim, Se-Young Choi, Sun-Hee Kim, Bong-Sik Yun, Ick-Dong Yoo,
Nanga. Ravi Prakash Reddy, Ho Sup Yoon, and Kyong-Tai Kim
accepted May 3, 2006
ABSTRACT
Isoliquiritigenin, one of the major constituents of Glycyrrhiza uralensis (licorice), is a natural pigment with a simple chalcone structure 4,2,4-trihydroxychalcone. In this study, isoliquiritigenin showed selective H2 histamine receptor (H2R) antagonistic effect and remarkably reduced several H2R-mediated physiological re- sponses. Preincubation of U937 and HL60 hematopoietic cells with isoliquiritigenin significantly inhibited H2R agonist-induced cAMP response in a concentration-dependent manner without affecting the viability of cells. Isoliquiritigenin also blocked the binding affinity of [3H]tiotidine to membrane receptors in HL-60 cells. Isoliquiritigenin did not affect the elevation of cAMP levels induced by cholera toxin, forskolin, or isoproterenol, indicatingthat the action site of isoliquiritigenin is not Gs protein, effector enzyme, adenylyl cyclase, or 2-adrenoceptor.
Isoliquiritigenin affected neither H1R- nor H3R-mediated signaling. In molecular docking studies, isoliquiritigenin exhibited more favorable interac- tions with H2R than histamine. Isoliquiritigenin prominently inhib- ited H2R selective agonist dimaprit-induced cAMP generation in MKN-45 gastric cancer cell. Moreover, isoliquiritigenin reduced gastric acid secretion and protected gastric mucosal lesion for- mation in pylorus-ligated rat model.
Taken together, the results demonstrate that isoliquiritigenin is an effective H2R antagonist and provides the basis for designing novel H2R antagonist.
"""""""
The entire Paper can be found here:
http://www.ncbi.nlm.nih.gov/pubmed/16675659
How many symptoms on that list do you have to have to be considered having MCAS?
There are no hard and fast rules. The good thing about MCAS, however, is that there is affordable testing available. Would you mind enumerating your symptoms? That would gives a "feel" for whether you might have MCAS or not.
You may also want to look at a presentation on Systemic Mast Cell Disease. Page 4 illustrates how MCAS may manifest itself and the rest of the document is full of case studies.
Let us know if you have any questions.
You may also want to look at a presentation on Systemic Mast Cell Disease. Page 4 illustrates how MCAS may manifest itself and the rest of the document is full of case studies.
Let us know if you have any questions.
Looked through they symptoms and didn't know what MANY of them even were!! I counted 23 that I did have.. Yes I have read about the MAST cell theory, and the B Cell theory, and the Entero virus theory, and the Bio Toxin Theory, LYME ..and and and and... Now I just think I fall in to the MENTAL category!!!!!!
So if it is Mast Cell - is there a treatment for this??
So if it is Mast Cell - is there a treatment for this??
OK, I guess it would be silly on my part to tell you that there is a good chance that you have MCAD, don't you think? 
The good thing about MCAD is that: 1) it is testable and, 2) it is treatable!
How about starting with some testing? There is a mast cell specialist at Stanford. How far way are you from there? His name is Jason Gotlib M.D., M.S. In any case, any decent immunologist should be able to order three tests: serum tryptase, 24-hour urinary N-methylhistamine and 24-hour urinary Prostaglandin D2. You may also want to take this with you, written by a mast cell expert (Dr. Afrin): MCAS Primers for Physicians.
Good luck and let me know if you have any questions!
The good thing about MCAD is that: 1) it is testable and, 2) it is treatable!
How about starting with some testing? There is a mast cell specialist at Stanford. How far way are you from there? His name is Jason Gotlib M.D., M.S. In any case, any decent immunologist should be able to order three tests: serum tryptase, 24-hour urinary N-methylhistamine and 24-hour urinary Prostaglandin D2. You may also want to take this with you, written by a mast cell expert (Dr. Afrin): MCAS Primers for Physicians.
Good luck and let me know if you have any questions!
There are a number of herbals that can shut down the inflammatory cascade/cytokines like the ones mentioned in the videos (similarly to the Nuroprotek that Theoarides has patented).
Some are very effective at that in my experience and will bring a lot of relief to symptoms including fatigue but it's no cure, they won't remove the underlying cause(s) whatever they are.
Then there's the question of using this approach long-term, meaning several years, and what effects this kind of immuno-modulation might have which nobody knows for sure.
Some are very effective at that in my experience and will bring a lot of relief to symptoms including fatigue but it's no cure, they won't remove the underlying cause(s) whatever they are.
Then there's the question of using this approach long-term, meaning several years, and what effects this kind of immuno-modulation might have which nobody knows for sure.
I am seeing Dr. Kogelnik and he is an immunologist along with many other Initials... He is convinced this is a viral illness hidden in the B cells... I will run the Mast Cell theory by him... I am so tired... I am just theory'd out! I will look at the info.. My Doc was originally at Stanford and just started his clinic Open Medicine ... to treat CFS/ME and is involved with the most informed ME docs... i am guessin if this was impt... he would be suspecting it ... unless he has his head in the sand and being very myopic with the treatment of Rituxan.
Problem is, very few MD's are aware of Mast Cell Activation Syndrome. Most know about mastocytosis and that it is rare so they quickly discount mast cell issues.
Have you been diag with this disorder??
I am currently in the middle of testing. Should have results in a week or so. I will share.
Well make sure to keep me posted will you??? Good luck!!
