Helminth therapy?This is an excellent review.
Any suggestions regarding:
“treatments that support the human immune system”?
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Helminth therapy?This is an excellent review.
Any suggestions regarding:
“treatments that support the human immune system”?
That's very interesting that EBV and CMV reduce VDR activation and expression as an immune evasion strategy. That's news to me. I've added those two studies to my list of immune evasion strategies used by ME/CFS viruses.
EBV also does other things for immune evasion purposes though:
EBV makes a "fake" (homologue) version of the human cytokine IL-10 in order to turn down the antiviral immune response. 1
EBV makes a protein called LMP-1 which can induce IL-10, again to turn down antiviral immunity.
EBV inhibits antigen presentation on MHC II, to protect virally-infected cells from immune recognition and attack. 1
EBV utilizes DNA methylation to cloak itself from immune detection. 1
The main thing you're getting out of the VDR are those antibiotic chemicals.
Besides, antibiotics don't touch viruses.
google: defensin VDR viruses, cathelicidin VDR viruses
Viruses obviously mess around VDR to establish their own persistence, not to help "fellow" bacteria:
Hepatitis B virus downregulates vitamin D receptor levels in hepatoma cell lines, thereby preventing vitamin D-dependent inhibition of viral transcription and production
https://molmed.biomedcentral.com/articles/10.1186/s10020-018-0055-0
Recently studies (Chan et al., 2015; Wong et al., 2015; Chen et al., 2015) demonstrated a correlation between low serum vitamin D levels in chronic HBV patients and high levels of viral replication. These studies raised the possibility that vitamin D levels inhibit HBV replication. In contrast, our in-vitro study showed that Vitamin D does not affect the rate of HBV replication, and downregulates VDR levels in the presence of the virus, thereby attenuating vitamin D signal transduction.
Vitamin D plays a crucial role in the regulation of genes central to protection against microbe invasion, such as the induction of the expression of antimicrobial peptides (also known as host defense peptides) such as CAMP and defensin. These peptides were demonstrated to disrupt the integrity of the microbe membrane, resulting in its death (Gombart, 2009). In addition, Vitamin D regulates the immune system by managing the expression of TNFα (Golovko et al., 2005), one of the most important pro-inflammatory and pro-immune cytokines. Therefore, downregulation of the vitamin D signaling pathway by viruses, can result in decreased production of antimicrobial peptides and cytokines and as a result, to attenuation of the immune response. Several studies have previously indicated that certain viruses can inhibit the Vitamin D signal transduction. In 2009, Yenamandra et al. demonstrated that VDR mRNA and protein levels were lower in EBV-transformed cells compared with primary B cells (Yenamandra et al., 2009). A few years earlier, Haug et al. reported a marked decrease in serum Calcitriol levels in human immunodeficiency virus (HIV)-infected patients, that correlated with the degree of immunodeficiency and patient survival (Haug et al., 1994). Therefore, in this study, we compared the activation of both TNFa and CAMP in HepG2 cell versus HepG2.2.15 cells following Cacitriol stimulation. Indeed, while the addition of Calcitriol upregulates both CAMP and TNFα expression in HepG2 cells, significantly less transcription of these genes was observed in HepG2.2.15 cells. These findings suggest that HBV can repress the activation of the immune system by downregulating the vitamin D signaling pathway.
etc
Symptom changes in 90% of patients with autoimmune conditions when EMF blocked
http://www.greenmedinfo.com/blog/gr...ows-shielding-emf-improves-autoimmune-disease
References T. Marshall paper.
In this groundbreaking study, it is also telling that the researchers found the therapeutic efficacy of the silver-coated caps to be so theoretically plausible that they decided the idea of using a control group was unethical.
Hehe, as soon as anyone do a formally "improper" study there is always a feedback like this as if the anti inflammatory drugs people use to copy with their symptoms passed any proper double-blind studies...
There is no excuse for nit-picking either:
Electrosensitives: the new cash cow of the woo industry
"In a provocation study, an electrosensitive person sits in a room with the source of electromagnetic waves hidden from view: they don’t know whether it is switched on or not. There have been 36 such studies published to date. This is very active work. This field has not been neglected. Thirty-three have shown that the subjects were unable to tell if the signal was present or absent, and the other three were flawed."