Mastocytosis: Diagnosis, Classification, and Therapy

[nanonug]

This is a very nice document by the European Competence Network on Mastocytosis:

Mastocytosis: Diagnosis, Classification, and Therapy

 

[MNC]

Thanks for this.

 

[xchocoholic]

Hi nanonug,

In looking at page 31, I noticed that they didn't recommend treating for h pylori for peptic
ulcers. Is it possible that this area of medicine has missed that ? Or is this info old ?

They mentioned treating neuro symptoms with h1s too. What's up with that ?

Tc .. X

 

[nanonug]

In looking at page 31, I noticed that they didn't recommend treating for h pylori for peptic ulcers.

These would be for H. pylori-negative peptic ulcers, caused by excessive histamine leading to increased stomach acid.

They mentioned treating neuro symptoms with h1s too. What's up with that ?

H1/H2 blockers appear to be "standard practice" for mast cell activation disorders. I suspect this is due to the auto-excitatory nature of histamine on mast cells. However, there might be other reasons I am not aware of.

 

[xchocoholic]

I can tell from experimenting with h1 mc meds, including Benadryl, and Klonopin that h1s don't stop my myoclonus / jerking.
Klonopin nails it tho. So I'm surprised that they'd suggest using mc meds for neuro problems. It is just a chart
tho. Lol.

tc .. X

 

[nanonug]

So I'm surprised that they'd suggest using mc meds for neuro problems.

What I found most interesting was the suggestion of using cromolyn sodium for neuro symptoms. Cromolyn sodium pretty much stays in the gut so I guess the old adage of "it's all in your gut" might old true after all. In my case, there is definitely a very strong correlation between gut and neurological symptoms.