Mast cell meds/adrenals

[outdamnspot]

A family friend who's a retired GP thinks I have MCAS and suggested trying an otc h1/h2 blocker to help curb my food intolerances. However, I was nervous because of how generally frail and sensitive I am. The logic is probably a bit shaky but when I am having histamine reactions, I am often 'energized', even though it's unpleasant adrenaline type energy, so I was wondering if antihistamines tend to lower cortisol or crash people's adrenals?

 

[Blake2e]

A family friend who's a retired GP thinks I have MCAS and suggested trying an otc h1/h2 blocker to help curb my food intolerances. However, I was nervous because of how generally frail and sensitive I am. The logic is probably a bit shaky but when I am having histamine reactions, I am often 'energized', even though it's unpleasant adrenaline type energy, so I was wondering if antihistamines tend to lower cortisol or crash people's adrenals?

You very likely have secondary POTS (secondary to your allergies/mast cells) going on as well. Same exact thing happens to me. Drugs that decrease histamine or block histamine receptors should help with that dirty adrenalized feeling youre getting. That adrenaline is your body's response to excess histamine. Adrenaline is an antihistamine. I would give the h1 and h2 blockers a try.

 

[outdamnspot]

You very likely have secondary POTS (secondary to your allergies/mast cells) going on as well. Same exact thing happens to me. Drugs that decrease histamine or block histamine receptors should help with that dirty adrenalized feeling youre getting. That adrenaline is your body's response to excess histamine. Adrenaline is an antihistamine. I would give the h1 and h2 blockers a try.

What time of day do you take them?

 

[Blake2e]

What time of day do you take them?

Whenever I feel I need them, regarding generation 2 H1s. With the gen 1 H1s its better to take around bedtime as they usually are sedating.

 

[outdamnspot]

Whenever I feel I need them, regarding generation 2 H1s. With the gen 1 H1s its better to take around bedtime as they usually are sedating.

Do they tend to 'crash' you?

 

[Blake2e]

Do they tend to 'crash' you?

Ive never experienced a crash or a rebound, though the gen 1 H1s usually make me feel like sedated crap when they start working so I only take them if nothing else is working for sleep. Some say there might be a rebound sort of effect if after long term use you drop it cold turkey, but I havent experienced this either.