Just about all of my current symptoms are explained via histamine. That ranges from the terrible insomnia (with histamine being an alertness neurotransmitter, and diphenhydramine usually providing sleep for me), to the bottoms of my feet being sore in the morning (since hands and feet are dense with mast cells, these areas being most likely to be injured from contact with the world). The H4 receptors in the hypothalamus might even explain the temperature dysregulation. Then there are the burning eyes, dyspnia, etc., it goes on and on.
However, I'm thinking that the etiology is fairly straightforward in me and doesn't require any pathology (such as hyperplasia or mast cell defects) other than this: MTHFR mutation makes for a backing up of systemic histamine, that would otherwise be degraded in normal systems. The chronic excess of histamine results in mast cells becoming unstable. That can take place because of a sort of pan-autocrine effect (I've been meaning to see if such effect is known to exist). Alternately, the excess histamine might activate some leukocyte (a monocyte lineage would be a good candidate for that), which releases some cytokine that in turn destabilizes mast cells.
I think of an old Western movie where somebody is transporting nitroglycerin in a wagon. In the cool morning, the nitro is stable; but as it gets hotter in the daytime sun, it becomes more and more unstable until any small shaking or jarring might set it off. Such are destabilized mast cells.
What to do? Break down the histamine, blockade the histamine, stabilize mast cells. Inhibiting histamine synthesis is probably not viable.
Still, for others here, the main symptoms probably come from being poisoned (by products of internal microbes, or else from external chemicals and molds etc, or else leaky gut can make almost any benign protein into a seeming poison). I'd get re-poisoned that way from too much sugar = candidiasis. Others here probably suffer most from some persistent and flaring infection - I've had a raw throat and enlarged submandibular lymph nodes for years, even though that's gotten better year by year. Even so, I'm solidly in the histamine camp for now.
